Functionalization Toward single molecule DNA devices

• Project/Area Number: 20710097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Aoyama Gakuin University
• Principal Investigator: MITSUI Toshiyuki Aoyama Gakuin University, 理工学部, 准教授 (40406814)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 生物物理 / ナノ材料 / マイクロナノデバイス

Research Abstract

Chemically or Physically modified Nanopoes have been fabricated by deposition organic molecules or evaporating Au on the SiN membrane. We have realized that both modified nanopores reduce the chance of DNA clogging into nanopores by using a fluorescence microscope to observe the DNA translocation directly. In addition, we have investigated the way to remove DNA's after DNA's get stuck in nanopores. AC voltage adding to DC offset voltage induces to remove the stuck DNA's.

Research Products

• [Journal Article] Metal- and Hydrogen-Bonding Competition during Water Adsorption on Pd(111) and Ru(0001) (2009)
  • Author(s): Mous Tatarkhanov, D. Frank Ogletree, Franck Rose, Toshiyuki Mitsui, Evgeny Fomin, Sabine Maier, Mark Rose, Jorge I. Cerd, Miquel Salmeron
  • Journal Title: J. Am. Chem. Soc. 131(51) Pages: 18425-18434
  • Peer Reviewed
• [Presentation] DNA dynamics near modi￣ed solid state nanopore (2010)
  • Author(s): Yoshitaka Hayashi, Genki Ando, Kaya Kobayashi, Toshiyuki Mitsui
  • Organizer: アメリカ物理学会
  • Place of Presentation: Portland, Oregon
  • Year and Date: 2010-03-16
• [Presentation] DNA dynamics near modified solid state nanopore (2010)
  • Author(s): Yoshitaka Hayashi, Genki Ando, Kaya Kobayashi, Toshiyuki Mitsui
  • Organizer: アメリカ物理学会
  • Place of Presentation: Portland, Oregon, USA
  • Year and Date: 2010-03-16
• [Presentation] Direct observation of DNA dynamics toward solid state nanopore studied by fluorescence microscopy (2009)
  • Author(s): Toshiyuki Mitsui
  • Organizer: American PhySiCs Society
  • Place of Presentation: Pittsburg PA USA
  • Year and Date: 2009-03-20
• [Presentation] Direct observation of DNA dynamics toward solid state nanopore studied by fluorescence microscopy (2009)
  • Author(s): Tomoharu Takita, Noriyuki Toyama, Kaya Kobayashi, Toshiyuki Mitsui
  • Organizer: アメリカ物理学会
  • Place of Presentation: Pittsburgh, Pennsylvania, USA
  • Year and Date: 2009-03-17
• [Presentation] Study of DNA Dynamics toward Solid State Nanopore Studied by Fluorescence Microscopy (2009)
  • Author(s): Toshiyuki Mitsui
  • Organizer: The March Annual Workshop
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2009-03-05
• [Remarks]
  • URL: http://www.phys.aoyama.ac.jp/~w3-mitsui/index.html