| Project/Area Number |
20710145
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎ゲノム科学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI Shunsuke Tokyo Medical and Dental University, 難治疾患研究所, 特任教員 (30431951)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | インプリンティング / ゲノム刷り込み / 有袋類 / 国際研究者交流 / オーストラリア / ゲノムインプリント / 進化 / エピジェネティクス / DNAメチル化 |
|---|
| Research Abstract |
Genomic imprinting is a unique regulatory mechanism of gene expression, causes monoallelic gene expression by silencing of one of two genes derived from both parents. In higher vertebrates, only mammals have genomic imprinting and it is essential for normal embryonic development. However, monoallelic gene expression has a critical demerit in that only one hit of recessive mutations could lead abnormal phenotypes immediately. In this research, we have developed the novel approach identifying imprinted loci from marsupial genomic DNA as the first step to investigate why and how genomic imprinting arose in mammalian evolution.
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