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Biogenesis of ion transporters and analysis of their functionalregulation

Research Project

Project/Area Number 20710161
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionTohoku University

Principal Investigator

SATO Yoko  Tohoku University, 大学院・工学研究科, 助教 (40455803)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords膜タンパク質 / トランスロコン / トポロジー / 生体膜 / チャネル
Research Abstract

The voltage sensors in voltage-dependent potassium channels (Kv channels) consist of the highly positively charged segment, S4, and the negatively charged segments, S2 and S3. How can such highly charged protein domains be efficiently inserted into biological membranes? In this study, we used in vitro translation and translocation experiments to evaluate interactions between residues in the voltage sensor of an archaeal potassium channel, KvAP, and their effect on the final topology in the endoplasmic reticulum (ER) membrane. These results suggest that insertion mechanism of the KvAP is different from plant and insect Kv channels.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2009 2008

All Presentation (6 results)

  • [Presentation] 魚住信之K+チャネル膜電位センサーのトポロジー形成機構の解明2009

    • Author(s)
      三島枝里子、佐藤陽子、張麗艶、阪口雅郎
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-10-22
    • Related Report
      2009 Final Research Report
  • [Presentation] K^+チャネル膜電位センサーのトポロジー形成機構の解明2009

    • Author(s)
      三島枝里子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 魚住信之K+チャネル膜電位センサーの形成機構の解明2009

    • Author(s)
      佐藤陽子、三島枝里子、張麗艶、阪口雅郎
    • Organizer
      日本生化学会東北支部第75回例会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] K^+チャネル膜電位センサーの形成機構の解明2009

    • Author(s)
      佐藤陽子
    • Organizer
      日本生化学会東北支部第75回例会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膜電位依存性KチャネルKvAPの膜挿入機構2009

    • Author(s)
      三島枝里子
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] イオン輸送系のトポロジー形成および活性調節2008

    • Author(s)
      佐藤陽子
    • Organizer
      招待セミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-06-04
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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