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Mechanistic Study of Cell Death by Using Cell Death Control Molecules

Research Project

Project/Area Number 20710163
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

DODO Kosuke  The Institute of Physical and Chemical Research, 袖岡有機合成化学研究室, 研究員 (20415243)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords細胞死 / アポトーシス / ネクローシス / ケミカルバイオロジー / 創薬科学 / ミトコンドリア
Research Abstract

Cell death is one of the most important systems for the maintenance of multicellular organisms. In this study, we performed the development and mechanistic study of cell death control molecules, i.e., inhibitors or inducers of cell death. As a result, we obtained some cell death inducers having unique cell death inducing properties. By using these compounds and modified probes, we determined some binding proteins as potent candidates of target molecules.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (37 results)

All 2011 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (25 results) Book (1 results)

  • [Journal Article] Identification of binding proteins of fusarielin A as actin and tubulin2010

    • Author(s)
      T.Noguchi-Yachide, K.Dodo, H.Aoyama, H.Fujimoto, M.Hori, Y.Hashimoto, H.Kobayashi
    • Journal Title

      Chem.Pharm.Bull 58

      Pages: 129-134

    • NAID

      40016900066

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation2010

    • Author(s)
      Y.Teng, K.Iuchi, E.Iwasa, S.Fujishiro, Y.Hamashima, K.Dodo, M.Sodeoka
    • Journal Title

      Bioorg.Med.Chem.Lett. 20

      Pages: 5085-5088

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] evelopment of Selective Inhibitors of Necrosis2010

    • Author(s)
      M.Sodeoka K.Dodo
    • Journal Title

      Chem.Rec. 10

      Pages: 308-314

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation2010

    • Author(s)
      Yuou Teng, 他6名
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 20 Pages: 5085-5088

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Selective Inhibitors of Necrosis2010

    • Author(s)
      Mikiko Sodeoka, 他1名
    • Journal Title

      The Chemical Record

      Volume: 10 Pages: 308-314

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Binding Proteins of Fusarielin A as Actin and Tubulin2010

    • Author(s)
      Tomomi Noguchi-Yachide, 他7名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 58

      Pages: 129-134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate2009

    • Author(s)
      K.Dodo, T.Minato, Y.Hashimoto
    • Journal Title

      Chem.Pharm.Bull 57

      Pages: 190-194

    • NAID

      110007042048

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate2009

    • Author(s)
      Kosuke Dodo, 他2名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57

      Pages: 190-194

    • NAID

      110007042048

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate Bioorg.2008

    • Author(s)
      K.Dodo, T.Minato, T.Noguchi-Yachide, M.Suganuma, Y.Hashimoto
    • Journal Title

      Med.Chem. 16

      Pages: 7975-7982

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural Development of Benzhydrol-type 1'-Acetoxychavicol Acetate (ACA) Analogs as Human Leukemia Cell-growth Inhibitors Based on QSAR Analysis2008

    • Author(s)
      T.Misawa, H.Aoyama, T.Furuyama, K.Dodo, M.Sagawa, H.Miyachi, M.Kizaki, Y.Hashimoto
    • Journal Title

      Chem.Pharm.Bull 56

      Pages: 1490-1495

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate2008

    • Author(s)
      Kosuke Dodo, 他4名
    • Journal Title

      Bioorganic & Medicinal Chemistry 76

      Pages: 7975-7982

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 天然物chaetocinおよびその類縁体のアポトーシス誘導メカニズム解明2011

    • Author(s)
      滕玉鴎、井内勝哉、〓〓孝介、岩佐江梨子、藤城信哉、濱島義隆、袖岡幹子
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規細胞死抑制剤の構造活性相関2011

    • Author(s)
      早水健二、〓〓孝介、山口卓男、清水忠、一丸直哉、袖岡幹子
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Development and mechanistic study of novel cell death inducer: elucidation of the molecular mechanism of oxidative-stress-induced necrosis2010

    • Author(s)
      S.Sato, K.Dodo, Y.Teng, S.Kamisuki, Y.Hashimoto, M.Sodeoka
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Development and mechanistic study of novel cell death inducer : elucidation of the molecular mechanism of oxidative-stress-induced necrosis2010

    • Author(s)
      Shinichi Sato, 他5名
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然物chaetocinおよびその類縁体のアポトーシス誘導メカニズム解明2010

    • Author(s)
      Y.Teng, K.Iuchi, K.Dodo, E.Iwasaa, S.Fujishiro, Y.Hamashima M.Sodeoka
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞死抑制剤IM-54のミトコンドリア機能障害に対する抑制作用2010

    • Author(s)
      K.Iuchi, Y.Teng, K.Dodo, T.Shimizu, Y.Mori, M.Sodeoka
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞死抑制剤IM-54のミトコンドリア機能障害に対する抑制作用2010

    • Author(s)
      Katsuya Iuchi, 他5名
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然物chaetocinおよびその類縁体のアポトーシス誘導メカニズム解明2010

    • Author(s)
      Yuou Teng, 他6名
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規細胞死抑制剤Indolyllactam(IL)誘導体の構造展開2010

    • Author(s)
      早水健二、〓〓孝介、山口卓男、清水忠、一丸直哉、袖岡幹子
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規細胞死誘導剤NecroTriggerをツールとしたネクローシス分子機構解明2010

    • Author(s)
      佐藤伸一, どど孝介, 滕玉鴎, 紙透伸治, 橋本祐一, 袖岡幹子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規細胞死誘導剤 NecroTrigger をツールとしたネクローシス分子機構解明2010

    • Author(s)
      佐藤伸一, 他6名
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Indolylmaleimide(IM)誘導体を出発点とした新規細胞死抑制剤の構造展開2009

    • Author(s)
      早水健二、清水忠、〓〓孝介、一丸直哉、袖岡幹子
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-26
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ネクローシスの分子機構解明を目指した新規細胞死誘導剤の開発2009

    • Author(s)
      佐藤伸一, 〓〓孝介, 滕玉鴎, 橋本祐一, 袖岡幹子
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 1'-Acetoxychavicol acetate(ACA)をリード化合物としたベンズヒドロール型新規細胞増殖抑制剤の創製研究2009

    • Author(s)
      三澤隆史, 青山洋史, 古山渓行, 〓〓孝介, 佐川森彦, 宮地弘幸, 木崎昌弘, 橋本祐一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] ネクローシスの分子機構解明を目指した新規細胞死誘導剤の創製2009

    • Author(s)
      佐藤伸一, 〓〓孝介, 滕玉鴎, 橋本祐一, 袖岡幹子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] フォトアフィニティーラベリングを用いたIM誘導体のターゲットタンパク質の同定2009

    • Author(s)
      一丸直哉, 清水忠, 滕玉鴎, 〓〓孝介, 袖岡幹子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 新規細胞死抑制剤IM-54の作用機序解明2009

    • Author(s)
      滕玉鴎, 〓〓孝介, 清水忠, 森靖典, 袖岡幹子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 新規細胞死抑制剤Indolylmaleimide(IM)誘導体の開発2009

    • Author(s)
      〓〓孝介, 清水忠, 笹森潤, 相原和行, 袖岡幹子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規細胞死抑制剤Indolylmaleimide (IM)誘導体の開発2009

    • Author(s)
      〓〓(どど)孝介, 他4名
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] l'-Acetoxychavicol acetate (ACA)をリード化合物としたベンズヒドロール型新規細胞増殖抑制剤の創製研究2009

    • Author(s)
      三澤隆史, 他7名
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1'-Acetoxychavicol acetate(ACA)をリード化合物とした新規細胞増殖抑制剤の創製研究2008

    • Author(s)
      三澤隆史, 青山洋史, 古山渓行, 〓〓孝介, 佐川森彦, 宮地弘幸, 木崎昌弘, 橋本祐一
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規細胞死抑制剤Indolylmaleimide(IM)誘導体の開発2008

    • Author(s)
      〓〓孝介, 加藤美穂, 笹森潤, 相原和行, 清水忠, 高橋昌弘, 袖岡幹子
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗がん剤耐性克服を目指した非アポトーシス型細胞死誘導剤の創製研究2008

    • Author(s)
      佐藤伸一, 〓〓孝介, 滕玉鴎, 橋本祐一, 袖岡幹子
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 新規細胞死抑制剤Indolylmaleimide (IM)誘導体の開発2008

    • Author(s)
      〓〓(どど)孝介, 他6名
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1'-Acetoxychavicol acetate (ACA)をリード化合物とした新規細胞増殖抑制剤の創製研究2008

    • Author(s)
      三澤隆史, 他7名
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      第27回メディシナルケミストリーシンポジウム
    • Related Report
      2008 Annual Research Report
  • [Book] 化学と生物,462008

    • Author(s)
      〓〓孝介, 袖岡幹子
    • Publisher
      ネクローシス抑制剤の開発:細胞死メカニズムの解明を目指して
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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