Creation of artificial transcription factors for artificial gene circuits
Project/Area Number |
20710165
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Living organism molecular science
|
Research Institution | Kyoto University |
Principal Investigator |
IMANISHI Miki Kyoto University, 化学研究所, 助教 (80362391)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 亜鉛フィンガー / 人工転写因子 / 遺伝子制御 |
Research Abstract |
Artificial gene circuits is expected to provide a new way to understand various biological events controlled by feedback regulations. Towards the usage of such artificial gene circuits, artificial DNA binding proteins with various DNA binding properties, such as DNA binding affinity, selectivity, kinetics et al., would be important tools. So artificial zinc finger-type DNA binding proteins and transcription factors with various properties for DNA binding were created and examined the functions. Metal-responsive artificial DNA binding proteins and transcription factors were also successfully created.
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Report
(3 results)
Research Products
(20 results)