| Project/Area Number |
20710173
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Hokkaido University |
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Principal Investigator |
NAMBA Kosuke Hokkaido University, 大学院・理学研究院, 講師 (50414123)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ムギネ酸 / ムギネ酸・鉄錯体トランスポーター / HvYS1 / ムギネ酸プローブ / 標識ムギネ酸 / ムギネ酸・鉄錯体 / アルカリ不良土壌 / L-アゼチジン-2-カルボン酸 / 実用的合成 / ファイトシデロフォア / 鉄錯体トランスポーター / クリック反応 / 鉄認識メカニズム |
|---|
| Research Abstract |
To drive the mechanistic studies of iron recognition in gramineous plant forward, it has been essential to establish efficient methods for mugineic acid derivatives to be utilized as molecular probes. We have recently found that the 2'-hydroxy group can serve as a potential clue for the labeling of mugineic acid analogues. On the basis of this discovery, we have established efficient method for the synthesis of various labeled mugineic acid. All of iron complexes of the synthetic labeled mugineic acid exhibit iron transport abilities through iron transporter. We thus succeed to establish the efficient method for introducing various labels to mugineic acid.
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