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Chemical approach for elucidating structure and function of a novel glycolipid stimulating the membrane-protein integration.

Research Project

Project/Area Number 20710174
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionSuntory Institute for Bioorganic Research

Principal Investigator

MAEDA Masahide  Suntory Institute for Bioorganic Research, 研究員 (80462290)

Research Collaborator NISHIYAMA Ken-ichi  岩手大学, 農学部付属寒冷バイオフロンティア研究センター, 教授 (80291334)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords天然物有機化学 / 複合糖脂質 / 膜蛋白質輸送 / 構造解析 / 膜蛋白暫輸送
Research Abstract

Integration of membrane-proteins into lipid membranes is strictly regulated with translocon, such as SecYEG complex and YidC. Recently, a novel integration-stimulating factor, suggested a sort of glycolipid, was found out in this integration process. In this study, we succeeded in extraction and purification of this factor from E. coli strain MC4100 and assumed a total structure of this integration factor by structural data obtained by NMR and MS analyses.

Report

(3 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A novel complete reconstitution system for membrane integration of the simplest membrane protein2010

    • Author(s)
      Nishiyama, K., Maeda, M., Abe, M., Kanamori, T., Shimamoto, K., Kusumoto, S., Ueda, T., Tokuda, H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 394(3)

      Pages: 733-736

    • NAID

      120002439245

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Patent(Industrial Property Rights)] 大腸菌膜タンパク質挿入因子2010

    • Inventor(s)
      楠本正一、島本啓子、前田将秀、西山賢一、徳田元、上田卓也、金森崇
    • Industrial Property Rights Holder
      サントリーホールディングス株式会社
    • Industrial Property Number
      2010-048520
    • Filing Date
      2010-03-05
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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