| Project/Area Number |
20710175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
KAWATANI Makoto The Institute of Physical and Chemical Research, 化合物ライブラリー評価研究チーム, 研究員 (50391925)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | UBL-UBA型ユビキチンレセプター / 阻害剤 / 癌 |
|---|
| Research Abstract |
The purpose of this study is to develop an anticancer agent targeting UBL-UBA family protein. I found that GUT-70, an antiproliferative compound, binds to ubiquilin 1. GUT-70 accumulated intercellular ubiquitinated proteins, and proteome analysis showed that GUT-70 is classified into the same cluster as a proteasome inhibitor. These results suggest that GUT-70 targets ubiquilin 1, thereby suppressing ubiqutin-proteasome system, resulting in the growth inhibition of cancer cells.
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