| Project/Area Number |
20750074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
NAKAMURA Shuichi Nagoya Institute of Technology, 大学院・工学研究科, 准教授 (20335087)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 不斉合成・反応 / 環境調和型触媒設計 / 有機合成化学 / 生理活性物質 / 環境調和型反応 / 有機化学 / 不斉触媒 |
|---|
| Research Abstract |
In order to develop the synthesis of chiral compounds, we designed novel organocatalysts and reagents having a coordinative group in their structures. Although enantioselective aldol reaction to ketone is generally difficult, the reaction using our novel organocatalysts afforded good results. Especially, biologically active convolutamydine derivatives can be prepared by using the organocatalysts. Furthermore, organocatalyst could be easily introduced into montmorillonite. The catalyst was readily reusable without significant loss of catalytic activity or enantioselectivity.
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