Development of Molecular Transformation Method Based on Transition-Metal-Catalyzed Reaction Involving Hydrogen-Boron Exchange
Project/Area Number |
20750076
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Synthetic chemistry
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Research Institution | Kyoto University |
Principal Investigator |
OHMURA Toshimichi Kyoto University, 工学研究科, 講師 (00378803)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 遷移金属触媒 / 立体選択的合成 / カスケード反応 / 官能基化 / 有機ホウ素化合物 / 有機ケイ素化合物 / 合成反応 / 結合形成 |
Research Abstract |
An efficient platinum-catalyzed reaction involving hydrogen-boron exchange on the carbon-carbon double bond has been established, which results in regioand stereoselective construction of organoboron compounds. A rhodium-catalyzed addition reaction of hydrosilane, which is formed in the hydrogen-boron exchange, to the carbon-carbon double bond has also been developed. Finally, sequential molecular transformation involving stereoselective construction of both carbon-carbon double bond and stereogenic carbon centers has been achieved by applying those two reactions.
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Report
(3 results)
Research Products
(13 results)