Development of Catalytic Cyclization Reaction for the Construction of Oxindole Ring System
Project/Area Number |
20750078
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Synthetic chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
TOMOYA Miura Kyoto University, 大学院・工学研究科, 講師 (10378804)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 合成化学 / 有機化学 / 有機工業化学 / 有機合成化学 / 触媒反応 / 環化反応 / オキシインドール / パラジウム / アリールボロン酸 / トリフルオロアセタミド / 抗癌薬 / ジボロン / ロジウム |
Research Abstract |
A new cyclization reaction occurred on treatment of 2-(alkynyl)aryl isocyanates with various nucleophiles such as organoboronic acids, amides, alcohols, and thiols in the presence of a palladium catalyst, leading to the stereoselective formation of 3-alkylideneoxindoles.
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Report
(3 results)
Research Products
(18 results)