| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The acrylamide derivatives of sulfonated glucosamine and uronic acid were synthesized as glycosaminoglycan model polymers. The polymers were bound to amyloid β peptides to inhibit the aggregation of peptides. The living radical polymerization of glycopolymers was investigated with RAFT reagents. The living radical polymerization provides the glycopolymers with thiol terminal, which were combined with gold substrates and gold nanoparticles. The glycopolymer hybrid materials showed the specific affinity to protein, pathogen and bacteria.
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