| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Heme oxygenase (HO) is an enzyme that catalyzes oxidative heme degradation. We recently have found a novel heme catabolic reaction by HO to produce new products in vitro. In this research project, the HO reactions were extensively studied by means of reaction analysis, structural analysis and theoritical calculation to clarify the novel HO reaction. The new heme catabolite was succesfully detected in mammalian cell culture so that the novel HO reaction can proceed in living organisms.
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