Development of novel boron-containing nucleotide analogues by using nucleoside H-boranophosphonate derivatives as precursors.
| Project/Area Number |
20750127
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
OKA Natsuhisa The University of Tokyo, 工学部, 准教授 (50401229)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 核酸 / ホウ素 / ホスホン酸 / DNA / ヌクレオシド / 核酸類縁体 / ボラノホスホン酸 / 核酸医薬 / ヌクレオチド / H-ボラノホスホン酸 / ボラノホスフェート / 次亜リン酸 |
|---|
| Research Abstract |
P-Boronated nucleotide analogues have attracted much attention as potential therapeutic agents against various diseases, such as cancer and AIDS. However, only a few kinds of P-boronated nucleotide analogues are currently available. In this project, we have developed a new P-boronated nucleotide analogue, which contains a BH_3 group and an H group on the phosphorus atom. In addition, we found that this nucleotide analogue (nucleoside H-boranophosphonate) works as a precursor of other P-boronated nucleotides including currently unavailable compounds by substituting the H group.
|
Report
(3 results)
Research Products
(54 results)
