| Project/Area Number |
20750127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKA Natsuhisa The University of Tokyo, 工学部, 准教授 (50401229)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 核酸 / ホウ素 / ホスホン酸 / DNA / ヌクレオシド / 核酸類縁体 / ボラノホスホン酸 / 核酸医薬 / ヌクレオチド / H-ボラノホスホン酸 / ボラノホスフェート / 次亜リン酸 |
|---|
| Research Abstract |
P-Boronated nucleotide analogues have attracted much attention as potential therapeutic agents against various diseases, such as cancer and AIDS. However, only a few kinds of P-boronated nucleotide analogues are currently available. In this project, we have developed a new P-boronated nucleotide analogue, which contains a BH_3 group and an H group on the phosphorus atom. In addition, we found that this nucleotide analogue (nucleoside H-boranophosphonate) works as a precursor of other P-boronated nucleotides including currently unavailable compounds by substituting the H group.
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