| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
By chemically modifying RNA with azobenzene moieties, whose molecular structures change greatly with light irradiation, photoresponsive RNA is prepared. By using the photoisomerization of introduced azobenzene, formation and dissociation of RNA/RNA and RNA/DNA duplex has been photoregulated. Furthermore, multiple azobenzenes have been introduced to a ribozyme with enzymatic activity, and photoswitching of RNA cleavage at a specific site has been realized. The photoresponsive RNA is promising to be used for photoswitching RNA function.
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