Selective synthesis of luminescent metal nanoclusters for intracellular imaging
| Project/Area Number |
20750135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Doshisha University |
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Principal Investigator |
HITOMI Yutaka Doshisha University, 理工学部, 准教授 (20335186)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 金ナノ粒子 / イメージング / ポルフィリン / 蛍光 / 金ナノクラスター / 発光 / 保護配位子 / マンガン / 亜鉛 / 鉄 / 水溶性 / 細胞 / 粒子径制御 / 硫黄原子 / 多座配位子 |
|---|
| Research Abstract |
A new porphyrin-based passivant was synthesized which has two disulfide bonds in the same direction. Small gold nanoclusters were easily obtained when gold(III) ion was reduced in the presence of the passivants. Resulting gold nanoclusters exhibited an intense fluorescence due to the porphyrin molecules. Gold nanoparticles prepared with manganese-inserted porphyrin passivants accelerated the relaxation of water protons, indicating that the nanoparticles could be used as a MRI contrast agent.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] An in situ quick XAFS spectroscopy study on the formation mechanism of small gold nanoparticles supported by porphyrin-cored tetradentate passivants2011
Author(s)
Junya Ohyama, Kentaro Teramura, Yasuhiro Higuchi, Tetsuya Shishido, Yutaka Hitomi, Kazuki Aoki, Takuzo Funabiki, Masahito Kodera, Kazuo Kato, Hajime Tanida, Tomoya Uruga, Tsunehiro Tanaka
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Journal Title
Physical Chemistry Chemical Physics 13
Pages: 11128-11135
Related Report
Peer Reviewed
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