Design of cationic molecule as a potential B-Z transition inducer

• Project/Area Number: 20750140
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemistry related to living body
• Research Institution: Kyushu University
• Principal Investigator: SHIMADA Naohiko Kyushu University, 先導物質化学研究所, 学術研究員 (10423972)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 生体関連高分子化学 / 核酸 / 高分子構造・物性

Research Abstract

The conformational transition from right-handed B-DNA to left-handed Z-DNA (B-Z transition) has received increased attention recently because of its potential roles in biological systems and its applicability to bionanotechnology. In this study, I designed cationic comb type copolymers as a B-Z transition inducer.

Research Products

• [Journal Article] B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer (2009)
  • Author(s): N. Shimada, A. Kano, A. Maruyama
  • Journal Title: Adv. Funct. Mater. 19 Pages: 3590-3595
  • Peer Reviewed
• [Journal Article] Design of cationic graft copolymers as a potential inducer of B-Z transition (2009)
  • Author(s): N. Shimada, A. Kano, A. Maruyama
  • Journal Title: Nucleic Acids Symposium Series 53 Pages: 251-252
• [Journal Article] B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer (2009)
  • Author(s): N.Shimada, et al.
  • Journal Title: Adv. Funct. Mater. 19 Pages: 3590-3595
  • Peer Reviewed
• [Journal Article] Design of cationic graft copolymers as a potential inducer of B-Z transition (2009)
  • Author(s): N.Shimada, et al.
  • Journal Title: Nucleic Acids Symposium Series 53 Pages: 251-252
• [Journal Article] Effect of cationic comb-type copolymer on the B-Z transition of poly(dG-dC) poly(dG-dC) (2008)
  • Author(s): N. Shimada, A. Kano, A. Maruyama
  • Journal Title: Nucleic Acids Symposium Series 52 Pages: 113-114
• [Journal Article] Effect of cationic comb-type copolymer on the B-Z transition of poly(dG-dC)-poly(dG-dC) (2008)
  • Author(s): N. Shimada, et.al.
  • Journal Title: Nucleic Acids Symposium Series 52 Pages: 113-114
• [Presentation] カチオン性くし型共重合体による生体分子の二次構造制御 (2009)
  • Author(s): 嶋田直彦
  • Organizer: 大学間連携第5回物質合成シンポジウム
  • Place of Presentation: 京都大学
  • Year and Date: 2009-11-19
• [Presentation] DNAのB-Z転移を誘起するカチオン性くし型共重合体の設計 (2009)
  • Author(s): 嶋田直彦
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-16
• [Presentation] DNAのB-Z転移に与えるカチオン性くし型共重合体の効果 (2009)
  • Author(s): 嶋田直彦
  • Organizer: 第19回バイオ・高分子シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2009-07-29
• [Presentation] カチオン性くし型共重合体がDNAのB-Z転移に与える影響 (2009)
  • Author(s): 嶋田直彦
  • Organizer: 平成20年度九州支部有機材料研究会
  • Place of Presentation: 九州工業大学
  • Year and Date: 2009-02-28
• [Presentation] DNAのB-Z転移に与えるカチオン性くし型共重合体の効果 (2008)
  • Author(s): 嶋田直彦
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2008-09-24