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Development of chimeric protein based on the silk fibroin and high calcium binding motifs for bone regeneration.

Research Project

Project/Area Number 20750174
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Polymer/Textile materials
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

NAKAZAWA Yasumoto  Tokyo University of Agriculture and Technology, 工学部, 助教 (20456255)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords絹フィブロイン / 骨再生 / 核磁気共鳴法 / キメラタンパク質
Research Abstract

For bone tissue engineering, we produced a new silk-like peptide, En(AGSGAG)m. This model peptide consists of the crystalline region of the silk fibroin from Bombyx mori, (AGSGAG), and a poly-glutamic acid region to improve the water solubility and Ca2+ binding ability. In this study, we performed structural and functional analyses for the molecular design of biomaterials for bone regeneration.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] 固体NMR法を用いた絹フィブロインの精密構造解析および生体材料への展開2010

    • Author(s)
      中澤靖元
    • Journal Title

      高分子論文集 (印刷中)

    • NAID

      10026584544

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yasumoto Nakazawa and Tetsuo Asakura; Structural Characterization of Silk-Based Water-Soluble Peptides (Glu)n(Ala-Gly-Ser- Gly-Ala-Gly)4 (n = 4-8) as a Mimic of Bombyx mori Silk Fibroin by 13C Solid-State NMR2009

    • Author(s)
      Aya Nagano, Yuka Kikuchi, Hirohiko Sato
    • Journal Title

      Macromolecules 42

      Pages: 8950-8958

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural Characterization of Silk-Based Water-Soluble Peptides(Glu)n(Ala-Gly-Ser-Gly-Ala-Gly)_4(n=4-8)as a Mimic of Bombyx mori Silk Fibroin by ^<13>C Solid-State NMR2009

    • Author(s)
      Aya Nagano, Yuka Kikuchi, Hirohiko Sato, Yasumoto Nakazawa, Tetsuo Asakura
    • Journal Title

      Macromolecules 42

      Pages: 8950-8958

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 固体NMR法を用いた絹フィブロインの精密構造解析および生体材料への展開

    • Author(s)
      中澤靖元
    • Journal Title

      高分子論文集 (In press)

    • NAID

      10026584544

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of Silk Fibroin from Bombyx mori with High Calcium Binding Ability and Application to Regenerated Materials for Bone.2009

    • Author(s)
      Yasumoto Nakazawa, Yumi Tanioka, Tetsuo Asakura
    • Organizer
      Third International Conference on Mechanics of Biomaterials & Tissues
    • Place of Presentation
      Clearwater Beach, Florida, USA
    • Year and Date
      2009-12-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of Silk Fibroin from Bombyx mori with High Calcium Binding Ability and Application to Regenerated Materials for Bone2009

    • Author(s)
      Yasumoto Nakazawa, Yumi Tanioka, Tetsuo Asakura
    • Organizer
      Third International Conference on Mechanics of Biomaterials & Tissues
    • Place of Presentation
      Clearwater Beach, Florida, USA
    • Year and Date
      2009-12-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structure of silk fibroins and application to biomaterials.2009

    • Author(s)
      Tetsuo Asakura, Chikako Tanaka, Yasumoto Nakazawa
    • Organizer
      NIMSWeek09
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2009-06-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Structure of silk fibroins and application to biomaterials2009

    • Author(s)
      Tetsuo Asakura, Chikako Tanaka, Yasumoto Nakazawa
    • Organizer
      NIMSWeek09
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨・歯再生へ向けた高機能化絹タンパクの開発と評価2008

    • Author(s)
      谷岡由望, 中澤靖元, 立松謙一郎, 朝倉哲郎
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市立大学
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 絹様タンパク質とモデルペプチドの固体NMR構造解析とその応用2008

    • Author(s)
      山口恵理香, 中澤靖元, 朝倉哲郎
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市立大学
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] グルタミン酸連鎖を付与した新規絹様ペプチド、(E)n(AGSGAG)mの固体・溶液構造とバイオマテリアルへの応用指針2008

    • Author(s)
      佐藤博彦, 菊池有加, 中澤靖元, 朝倉哲郎
    • Organizer
      第57回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-05-29
    • Related Report
      2009 Final Research Report
  • [Presentation] グルタミン酸連鎖を付与した新規絹様ペプチド、 (E)n(AGSGAG)mの固体・溶液構造とバイオマテリアルへの応用指針2008

    • Author(s)
      佐藤博彦, 菊池有加, 中澤靖元, 朝倉哲郎
    • Organizer
      第57回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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