Development of chimeric protein based on the silk fibroin and high calcium binding motifs for bone regeneration.
| Project/Area Number |
20750174
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Polymer/Textile materials
|
|---|
| Research Institution | Tokyo University of Agriculture and Technology |
|---|
Principal Investigator |
NAKAZAWA Yasumoto Tokyo University of Agriculture and Technology, 工学部, 助教 (20456255)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 絹フィブロイン / 骨再生 / 核磁気共鳴法 / キメラタンパク質 |
|---|
| Research Abstract |
For bone tissue engineering, we produced a new silk-like peptide, En(AGSGAG)m. This model peptide consists of the crystalline region of the silk fibroin from Bombyx mori, (AGSGAG), and a poly-glutamic acid region to improve the water solubility and Ca2+ binding ability. In this study, we performed structural and functional analyses for the molecular design of biomaterials for bone regeneration.
|
Report
(3 results)
Research Products
(12 results)
