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Development of a method to control acoustic cavitation withdual-frequency ultrasound for therapeutic use

Research Project

Project/Area Number 20760104
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fluid engineering
Research InstitutionTohoku University

Principal Investigator

YOSHIZAWA Shin  Tohoku University, 大学院・工学研究科, 助教 (30455802)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsバイオ流体力学 / 超音波治療 / キャビテーション / マイクロバブル / HIFU / rectified diffusion
Research Abstract

Ultrasound treatment has attracted much attention as a treatment for cancer, and many researchers have investigated the method. One of the big topics of the investigation is to control of cavitation bubbles induced by therapeutic ultrasound. In this study, dual-frequency method was investigated to generate cavitation with lower intensity ultrasound and control the cavitation bubbles. The results showed that it is important to choose the frequency and the phase difference of the two-frequency ultrasound depending on the properties of the bubbles.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (1 results)

  • [Journal Article] High Intensity Focused Ultrasound Lithotripsy with Cavitating Microbubbles2009

    • Author(s)
      S. Yoshizawa, T. Ikeda, A. Ito, R. Ota, S. Takagi, Y. Matsumoto
    • Journal Title

      Med. Biol. Eng. Comput. 47

      Pages: 851-860

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 超音波キャビテーションとその治療応用2009

    • Author(s)
      吉澤晋, 梅村晋一郎, 松本洋一郎
    • Journal Title

      マテリアルインテグレーション Vol.22,No.6

      Pages: 48-53

    • Related Report
      2009 Final Research Report
  • [Journal Article] 超音波音場における微小気泡の成長(2周波数重畳法によるrectified diffusionの増強効果)2009

    • Author(s)
      吉澤晋, 高木周, 松本洋一郎
    • Journal Title

      日本機械学会論文集(B編) Vol.75,No.752

      Pages: 142-149

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 超音波音場における微小気泡の成長(2周波数重畳法による rectified diffusion の増強効果)2009

    • Author(s)
      吉澤晋、高木周、松本洋一郎
    • Journal Title

      日本機械学会論文集(B編) 75

      Pages: 89-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Intensity Focused Ultrasound Lithotripsy with Cavitating Microbubbles2009

    • Author(s)
      S.Yoshizawa, T.Ikeda, A.Ito, R.Ota, S.Takagi, Y.Matsumoto
    • Journal Title

      Medical & Biological Engineering & Computing 47

      Pages: 851-860

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波キャビテーションとその治療応用2009

    • Author(s)
      吉澤晋、梅村晋一郎、松本洋一郎
    • Journal Title

      マテリアルインテグレーション 6

      Pages: 48-53

    • Related Report
      2009 Annual Research Report
  • [Presentation] Tissue ablation using cavitating bubbles triggered by high intensity ultrasound pulse2009

    • Author(s)
      S. Yoshizawa, R. Takagi, S. Umemura
    • Organizer
      9th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Aix en Provence, France
    • Year and Date
      2009-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Tissue ablation using cavitating bubbles triggered by high intensity ultrasound pulse2009

    • Author(s)
      S.Yoshizawa, R.Takagi, S.Umemura
    • Organizer
      9th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      エクスアンプロヴァンス、フランス
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 強力集束超音波治療におけるキャビテーションによる加熱増強効果2009

    • Author(s)
      吉澤晋, 梅村晋一郎
    • Organizer
      第14回キャビテーションに関するシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-03-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 超音波キャビテーションとその治療応用2009

    • Author(s)
      吉澤晋, 梅村晋一郎, 松本洋一郎
    • Organizer
      第1回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-01-09
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Cavitation Detection with Subharmonic Emissions by Low Intensity Sustaining Ultrasound2008

    • Author(s)
      S. Yoshizawa, S. Umemura, Y. Matsumoto
    • Organizer
      2008 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Cavitation Detection with Subharmonic Emissions by Low Intensity Sustaining Ultrasound2008

    • Author(s)
      Shin Yoshizawa
    • Organizer
      2008 IEEE International Ultrasonics Symposium
    • Place of Presentation
      北京(中国)
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ultrasound Heating Enhanced with Acoustic Cavitation Induced by Pulsed Ultrasound2008

    • Author(s)
      Shin Yoshizawa
    • Organizer
      8th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      ミネアポリス(アメリカ)
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ultrasound Heating Enhanced with Acoustic Cavitation Induced by Pulsed Ultrasound2008

    • Author(s)
      S. Yoshizawa, S. Umemura, Y. Matsumoto
    • Organizer
      8th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Minneapolis, USA
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report
  • [Book] マイクロバブル最前線2009

    • Author(s)
      吉澤晋
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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