Development of a Measurement Method for Heat and Electrical Characteristic of a Red Blood Cell
Project/Area Number |
20760133
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Thermal engineering
|
Research Institution | Kyoto University |
Principal Investigator |
TATSUMI Kazuya Kyoto University, 大学院・工学研究科, 助教 (90372854)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 赤血球 / マイクロ流れ / インピーダンス計測 / 弾性率計測 / 医療工学 / マイクロ流路 / 可視化 / 変形能 / 流体制御 / 硬化赤血球 |
Research Abstract |
A microsensor that can measure the electrical impedance and deformability of a single red blood cell (RBC) using microchannels and membrane-type micro-electrodes was successfully developed in this study. Normal human RBC and glutaraldehyde treated rigidified RBC were used as samples to evaluate the validity and accuracy of the sensor. The RBCs were guided to the electrodes in high accuracy, and the impedance and resistance of the each cell could be measured continuously. Moreover, a novel method that can measure the deformability of the RBC by analyzing the time-series distribution of the resistance was proposed, and its validity was confirmed.
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Report
(3 results)
Research Products
(17 results)