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Study on imaging system for analysis of endothelial vascular function

Research Project

Project/Area Number 20760264
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Measurement engineering
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

NISHIDATE Izumi  Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 講師 (70375319)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords皮膚血流 / 血管拡張性 / 動脈血流入量 / 静脈容量 / 反応性充血 / 皮膚画像計測 / 可視化 / 皮膚色素 / ヘモグロビン / 血液
Research Abstract

To visualize the human skin hemodynamics, we investigated a method that is specifically developed for estimating the concentrations of oxygenated and deoxygenated blood in skin tissue from RGB digital color images. Monte Carlo simulation of light transport in skin tissue specifies a relation between the chromophore concentrations and the RGB-values. The total blood concentration can also be reconstructed. In vivo imaging of the total blood concentration was performed for 13 subjects during the upper limb occlusion at 50 and 250 mmHg-pressures, together with the strain-gauge plethysmograph (SPG). The arterial inflow, the venous capacitance, and time constant of venous outflow in skin tissue were calculated from the increase rate and the change of the total blood concentration. We confirmed that the arterial inflow, venous capacitance, and time constant of venous outfow in skin tissue obtained from the method correlate closely with those of limb measured by SPG.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Investigation of arterial inflow and venous capacitance in human skin by use of RGB images2009

    • Author(s)
      Izumi Nishidate
    • Journal Title

      SPIE Proceedings 7368

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing of skin chromophore concentration by use of RGB images2008

    • Author(s)
      I. Nishidate, K. Sasaoka, T. Yuasa, K. Niizeki, T. Maeda, Y. Aizu
    • Journal Title

      Optics Letters Vol.33,No.19

      Pages: 2263-2265

    • Related Report
      2009 Final Research Report
  • [Journal Article] Visualizing of skin chromophore concentration by use of RGB images2008

    • Author(s)
      Izumi Nishidate
    • Journal Title

      Optics Letters 33

      Pages: 2263-2265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Monitoring of Skin Chromophore Contents by Use of Multispectral Diffuse Reflectance Images2009

    • Author(s)
      Aditya Wiswadarma
    • Organizer
      8^<th> Japan-Finland Joint Symposium on Optics in Engineering
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualization of human skin hemodynamics by use of RGB image2009

    • Author(s)
      I. Nishidate, H. Kaneko, K. Niizeki, T. Yuasa, T. Maeda, Y. Aizu
    • Organizer
      The XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Japan
    • Year and Date
      2009-08-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Visualization of human skin hemodynamics by use of RGB image2009

    • Author(s)
      Izumi Nishidate
    • Organizer
      The XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Investigation of arterial inflow and venous capacitance in human skin by use of RGB images2009

    • Author(s)
      I. Nishidate, H. Kaneko, T. Maeda, Y. Aizu, T. Yuasa, K. Niizeki
    • Organizer
      European Conferences on Biomedical Optics
    • Place of Presentation
      Germany
    • Year and Date
      2009-06-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Monitoring of microvascular reaction in skin tissue by use of multispectral reflectance Images2009

    • Author(s)
      Izumi Nishidate
    • Organizer
      4^<th> Asian and Pacific Rim Symposium on Biophotonics
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualization of skin hemodynamics by use of digital RGB image2008

    • Author(s)
      I. Nishidate, T. Maeda, Y. Aizu, K. Niizeki
    • Organizer
      International Topical Meeting on Information Photonics
    • Place of Presentation
      Japan
    • Year and Date
      2008-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Visualization of skin hemodynamics by use of digital RGB image2008

    • Author(s)
      Izumi Nishidate
    • Organizer
      International Topical Meeting on Information Photonics 2008
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] RGB画像に基づく皮膚血流量の画像化に関する検討2008

    • Author(s)
      西舘泉
    • Organizer
      第41回光波センシング技術研究会
    • Place of Presentation
      東京理科大学森戸記念館
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tuat.ac.jp/~bmp-mpg/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tuat.ac.jp/~bmp-mpg/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tuat.ac.jp/~bmp-mpg/index.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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