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Development of system identification methods for systems biology in yeast

Research Project

Project/Area Number 20760274
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Control engineering
Research InstitutionUtsunomiya University

Principal Investigator

AZUMA Takehito  Utsunomiya University, 工学研究科, 准教授 (60308179)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsシステムバイオロジー / システム同定 / 酵母 / 細胞分裂 / タンパク質ネットワーク / 制御工学 / システム生物学 / 最小二乗法 / ロバストネス解析
Research Abstract

Estimation problems of protein networks are defined for cell cycle in yeast and an approach to solve the problems has been proposed. In our approach, it is assumed that concentrations of proteins for cell cycle are obtained. Based on those concentrations of proteins, state space models are identified and the protein network for cell cycle is estimated. In numerical examples, the efficacy of our approach is demonstrated and the existence of unknown network paths is indicated. Moreover the roles of the estimated and unknown network paths are shown by using sensitivity analysis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (10 results)

  • [Journal Article] An Approach to Estimationof Protein Networks for Cell Cycle Based on Least-squares Method2010

    • Author(s)
      Takehito Azuma, Masachika Kurata, Noriko Takahashi, Shuichi Adachi
    • Journal Title

      Proceedings of the 4th International Conference on Sensing Technology (採択決定)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Estimation and Robustness Analysis of Protein Networks for 6-dimensional Cell Cycle Systems2010

    • Author(s)
      Takehito Azuma, Masachika Kurata, Noriko Takahashi, Shuichi Adachi
    • Journal Title

      Proceedings of 2010 IEEE Multi-conference on Systems and Control (採択決定)

    • Related Report
      2009 Final Research Report
  • [Journal Article] An Approach to Estimation of Protein Networks for Cell Cycle Based on Least-Squares Method Using Periodic Signals2010

    • Author(s)
      Noriko Takahashi, Takehito Azuma, Shuichi Adachi
    • Journal Title

      Proceedings of the 19th International Symposium on Mathematical Theory of Networks and Systems (採択決定)

    • Related Report
      2009 Final Research Report
  • [Journal Article] An Approach to Estimationof Protein Networks for Cell Cycle Based on Least-squares Method2010

    • Author(s)
      Takehito Azuma, Masachika Kurata, Noriko Takahashi, Shuichi Adachi
    • Journal Title

      Proceedings of the 4th International Conference on Sensing Technology (CD-ROM)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Estimation of Protein Networks in Yeast based on Least-squares Method, roceedings of ICROS-SICE2009

    • Author(s)
      Noriko Takahashi, Takehito Azuma, Shuichi Adachi
    • Journal Title

      International Joint Conference

      Pages: 196-199

    • Related Report
      2009 Final Research Report
  • [Journal Article] An Estimation of Protein Networks in Yeast based on Least-squares Method2009

    • Author(s)
      Noriko Takahashi, Takehito Azuma, Shuichi Adachi
    • Journal Title

      Proceedings of ICROS-SICE International Joint Conference 2009 (CD-ROM)

      Pages: 196-199

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Design of Gain-scheduled Congestion Controllers using State2008

    • Author(s)
      Takehito Azuma, Masashi Uchida
    • Journal Title

      Predictive Observers Vol.1

      Pages: 208-219

    • Related Report
      2009 Final Research Report
  • [Journal Article] An Experimental Result of System Identification over Networks using Delta-Sigma Transformation2008

    • Author(s)
      Takehito Azuma, Hirohisa Kato, Shuichi Adachi
    • Journal Title

      Proceedings of the 3rd International Conference on Sensing Technology (CDROM収録)

    • Related Report
      2009 Final Research Report
  • [Journal Article] A Design of Gain-scheduled Congestion Controllers using State Predictive Observers2008

    • Author(s)
      T. Azuma, M. Uchida
    • Journal Title

      Ineternational Journal on Smart Sensing and Intelligent Systems 1

      Pages: 208-219

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 6次元セルサイクルシステムに対するタンパク質ネットワーク推定とロバストネス解析2010

    • Author(s)
      東剛人
    • Organizer
      計測自動制御学会 第10回制御部門大会
    • Place of Presentation
      熊本大学(熊本県)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 6次元セルサイクルシステムに対するタンパク質ネットワーク推定とロバストネス解析2010

    • Author(s)
      東剛人
    • Organizer
      計測自動制御学会第10回制御部門大会
    • Related Report
      2009 Final Research Report
  • [Presentation] 周期信号に対する時変システム同定法に基づく酵母の細胞分裂ネットワークの推定2009

    • Author(s)
      高橋知子, 東剛人, 足立修一
    • Organizer
      第9回制御部門大会
    • Place of Presentation
      広島
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 周期信号に対する時変システム同定法に基づく酵母の細胞分裂ネットワークの推定2009

    • Author(s)
      高橋知子, 東剛人, 足立修一
    • Organizer
      計測自動制御学会第9回制御部門大会
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞分裂におけるタンパク質ネットワーク推定とロバストネス解析2009

    • Author(s)
      東剛人
    • Organizer
      計測自動制御学会システム・情報部門学術講演会
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] An Experimental Result of System Identification over Networks using Delta-Sigma Transformation2008

    • Author(s)
      Takehito Azuma, Hirohisa Kato, Shuichi Adachi
    • Organizer
      The 3rd International Conference on Sensing Technology
    • Place of Presentation
      Tainan(Taiwan)
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酵母のセルサイクルに関するタンパク質ネットワークの推定とロバストネス解析2008

    • Author(s)
      倉田真考, 榎戸聡東剛人, 足立修一
    • Organizer
      第37回制御理論シンポジウム
    • Place of Presentation
      鹿児島
    • Year and Date
      2008-09-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酵母のセルサイクルに関するタンパク質ネットワークの推定とロバストネス解析2008

    • Author(s)
      倉田真考, 榎戸聡, 東剛人, 足立修一
    • Organizer
      計測自動制御学会第37回制御理論シンポジウム
    • Related Report
      2009 Final Research Report
  • [Presentation] 結合定数と速度定数に着目したインターロックフィードバックモデルの感度解析2008

    • Author(s)
      篠崎隆宏, 東剛人
    • Organizer
      第51回自動制御連合講演会
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 熱ショック反応を応用した移動アルゴリズム2008

    • Author(s)
      輕部達也, 東剛人
    • Organizer
      第51回自動制御連合講演会
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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