An evolution of mammalian viviparity by retrotransposon
| Project/Area Number |
20770002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ONO Ryuichi Tokyo Medical and Dental University, 難治疾患研究所, 助教 (10401358)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | レトロトランスポゾン / 胎盤 / ゲノムインプリンティング |
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| Research Abstract |
I have previously identified Peg10 as a novel imprinted gene. Moreover, I have confirmed that Peg10 is a retrotransposon-derived gene and have an essential function for placental development. In this grant, to reveal the mechanism of Peg10 function in placenta, I have established Peg10 KO TS (Trophoblast Stem) cell lines from Peg10 KO mice. By comparing the gene expression between Peg10 KO TS cell lines and wild type TS cell lines, I could succeed in the isolation of Peg10 down regulated genes. These genes must be important for the evolution of mammalian viviparity.
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Report
(3 results)
Research Products
(25 results)
