| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The histone genes are highly repeated in genome and are transcribed at S phase. In this study, we analyzed the molecular feature of individual histone H3 in fission yeast. We showed that the binding partners of each histone H3 were varied throughout the cell cycle. There was a little difference among chromosome binding regions of these histone H3 proteins. However, we cannot be rule out the possibility that this result obtained it according to the different amount of histone H3. In addition, we reported that constitutive histone expression leads to centromere chromatin disruption and cell death.
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