Functional analysis of individual histone genes in fission yeast
Project/Area Number |
20770005
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Genetics/Genome dynamics
|
Research Institution | Kurume University |
Principal Investigator |
TAKAYAMA Yuko Kurume University, 分子生命科学研究所, 助教 (90461467)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ヒストン / セントロメア / 分裂酵母 / 転写制御 / S期 / 染色体 |
Research Abstract |
The histone genes are highly repeated in genome and are transcribed at S phase. In this study, we analyzed the molecular feature of individual histone H3 in fission yeast. We showed that the binding partners of each histone H3 were varied throughout the cell cycle. There was a little difference among chromosome binding regions of these histone H3 proteins. However, we cannot be rule out the possibility that this result obtained it according to the different amount of histone H3. In addition, we reported that constitutive histone expression leads to centromere chromatin disruption and cell death.
|
Report
(3 results)
Research Products
(14 results)