| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In this study, I revealed that crickets show age-related memory impairment (AMI) in long-term memory (LTM) formation in three types of learning ; to associate either olfactory, visual pattern or color with water reward. The AMI in each type of learning were fully recovered by administration of agonists of NO-cGMP signaling pathway. I also revealed that in the LTM formation mechanism, nicotinic acetylcholine receptors play role upstream of NO-cGMP pathway. Additional experiments were performed to test whether degradation of NO-cGMP signaling is responsible for AMI in cricket LTM formation
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