Neural mechanisms of age-related memory impairment in insect
Project/Area Number |
20770053
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Tohoku University |
Principal Investigator |
MATSUMOTO Yukihisa Tohoku University, 大学院・理学研究院, 研究員 (60451613)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 加齢性記憶障害 / 嗅覚学習 / 視覚学習 / 色覚学習 / 長期記憶 / 一酸化窒素 / 昆虫 / コオロギ / NO-cGMP系 / ニコチン型アセチルコリン受容体 / cAMP-PKA系 |
Research Abstract |
In this study, I revealed that crickets show age-related memory impairment (AMI) in long-term memory (LTM) formation in three types of learning ; to associate either olfactory, visual pattern or color with water reward. The AMI in each type of learning were fully recovered by administration of agonists of NO-cGMP signaling pathway. I also revealed that in the LTM formation mechanism, nicotinic acetylcholine receptors play role upstream of NO-cGMP pathway. Additional experiments were performed to test whether degradation of NO-cGMP signaling is responsible for AMI in cricket LTM formation
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Systemic RNA interference for the study of learning and memory in an insect2009
Author(s)
Takahashi T., Hamada, A., Miya waki, K., Matsumoto, Y., Mito, T Noji, S., and Mizunami, M.
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Journal Title
Journal of Neuroscience Methods 179
Pages: 9-15
Related Report
Peer Reviewed
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