The structural biological study of the macromolecular complex involved with formation of SARS-CoV virions
| Project/Area Number |
20770075
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
SAKAI Naoki Hokkaido University, 大学院・先端生命科学研究院, 助教 (20422008)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 構造生物学 / 蛋白質結晶学 / SARSコロナウイルス / X線結晶構造解析 / SARSコロナイルス |
|---|
| Research Abstract |
The aim of this study is elucidating the molecular basis of budding of SARS coronavirus (SARS-CoV). In the initiation stage of a budding of virion from infected host cell, N protein and M protein are interacted. This interaction is considered as a trigger of budding of SARS-CoV. To obtain a detail of the molecular mechanism of this phenomenon, I tried to solve the crystal structure of the macromolecular complex of N and M proteins and established the preparation method of N protein.
|
Report
(3 results)
Research Products
(32 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] バネト細胞α-defensinと腸内自然免疫 : クローン病との関わりを含めて2008
Author(s)
綾部時芳, 深谷梨恵, 坂井直樹, 前本篤男, 藍田知史, 河野透, 田邊裕貴, 高後裕
Organizer
自然免疫の最前線-3学会合同大会2008-, 第73回日本インターフェロン・サイトカイン学会学術集会, 第19回日本生体防御学会学術総会, 第45回補体シンポジウム
Place of Presentation
北海道大学
Year and Date
2008-07-10
Related Report
-
-
-
-
