| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The aim of this study is elucidating the molecular basis of budding of SARS coronavirus (SARS-CoV). In the initiation stage of a budding of virion from infected host cell, N protein and M protein are interacted. This interaction is considered as a trigger of budding of SARS-CoV. To obtain a detail of the molecular mechanism of this phenomenon, I tried to solve the crystal structure of the macromolecular complex of N and M proteins and established the preparation method of N protein.
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