Understanding of Signal Transduction Mechanism of Glutamate Receptor at Atomic Resolution
| Project/Area Number |
20770076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
UNNO Masaki Tohoku University, フロンティア応用原子科学研究センター, 准教授 (10359549)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | X線結晶解析 / グルタミン酸受容体 / 生体機能分子 / 薬物設計 / ダイシハーベイン / イオンチャンネル / グルタミン酸受容 / 薬剤設計 / X線結晶構造解析 / アイソフォーム / 選択性 / 機能制御 / 原子レベル / カイニン酸型 / 親和性 |
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| Research Abstract |
In order to understand the interaction ways between the glutamate receptors (GluK1, GluK2) and the dysiherbaine analogues, we determined the X-ray structure of these protein-ligand complexes.
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Report
(3 results)
Research Products
(32 results)
