| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Bacterial flagella has a reversible rotary motor that can rotate in both counterclockwise(CCW) and clockwise(CW) direction. The switching of the motor rotation direction is controlled by the complex located at the bottom of the basal body called the C ring, constructed from switch proteins. To understand the switching mechanisms of motor rotation in detail, we analyzed the C ring structures of the wild type and the CW-bias mutant by electron cryomicroscopy. Conformational change of the C ring by rotation direction switching was observed by the structure comparison between the wild type and the CW -bias mutant.
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