| Project/Area Number |
20770086
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
OHKI Izuru Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (80418574)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | クロマチン構造 / ヒストン修飾 / タンパク質 / 立体構造解析 / ヒストン / メチル化 / 立体構造 / 蛋白質 |
|---|
| Research Abstract |
In vertebrate, histones are modified in various combinations to produce the elaborate transcriptional control. In this study, we focus on the interaction of the trithorax MLL and polycomb Pc proteins to clarify the new regulatory mechanism by histone methylation. From structural analysis, two proteins were found to interact directly through a domain that has the opposite function of each other. This interaction was considered to adjust the balance of transcriptional activation and repression.
|
