Recognition of presequences of mitochondrial precursor proteins using dynamic equilibrium
| Project/Area Number |
20770087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SAITOH Takashi Kyushu University, デジタルメディシン・イニシアティブ, 助教 (00432914)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子認識及び相互作用 / 蛋白質 / 相互作用 / NMR / X線結晶構造解析 / ミトコンドリア / 構造生物学 / タンパク相互作用 |
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| Research Abstract |
In previous study, we proposed that a dynamic equilibrium between the multiple bound states is the molecular mechanism of the broadly selective specificity of the Tom20 receptor towards the divergent mitochondrial presequences. In this study, we carried out X-ray crystal structure analysis and NMR spectroscopy experiments using new complexes between Tom20 and presequenses. We obtained further information supporting the dynamic recognition model.
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Report
(3 results)
Research Products
(7 results)
