| Project/Area Number |
20770090
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
GOTO Naomi Iwate Medical University, 薬学部, 助教 (80403971)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
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| Keywords | V-ATPase / 小胞分泌 / 酸性オルガネラ / リソソーム / 小胞輸送 / 酸性環境 / オルガネラ / 破骨細胞 |
|---|
| Research Abstract |
Vacuolar type ATPase (V-ATPase) consists of 13 different subunits, and transports protons using energy from ATP hydrolysis. V-ATPase has variety of subunit isoforms, consistent with the different pH in acidic compartment. Previously, we showed that a3, one of 'a' subunit isoforms, was induced during osteoclast differentiation. In this study, we found the induction of d2 isoform and its interaction with a3 in differentiated cells. This interaction suggests that osteoclasts have a novel combination of V-ATPase isoforms.
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