• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

regulation of acidic organelle localization by V-ATPase

Research Project

Project/Area Number 20770090
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Structural biochemistry
Research InstitutionIwate Medical University

Principal Investigator

GOTO Naomi  Iwate Medical University, 薬学部, 助教 (80403971)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsV-ATPase / 小胞分泌 / 酸性オルガネラ / リソソーム / 小胞輸送 / 酸性環境 / オルガネラ / 破骨細胞
Research Abstract

Vacuolar type ATPase (V-ATPase) consists of 13 different subunits, and transports protons using energy from ATP hydrolysis. V-ATPase has variety of subunit isoforms, consistent with the different pH in acidic compartment. Previously, we showed that a3, one of 'a' subunit isoforms, was induced during osteoclast differentiation. In this study, we found the induction of d2 isoform and its interaction with a3 in differentiated cells. This interaction suggests that osteoclasts have a novel combination of V-ATPase isoforms.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Dynamic and functional assembly of the AAA peroxins, Pexlp and Pex6p, and their membrane receptor Pex26p involved in shuttling of the PTS1 receptor Pex5n in peroxisome biogenesis2008

    • Author(s)
      Yukio Fujiki, Non Miyata, Naomi Matsumoto, Shigehiko Tamura
    • Journal Title

      Biochemical Society transactions 36

      Pages: 109-113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 破骨細胞におけるV-ATPase a3サブユニット局在オルガネラの解析2009

    • Author(s)
      松元奈緒美、平郁子、中西真弓、二井將光
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 破骨細胞におけるV-ATPase a3サブユニット局在オルガネラの解析2009

    • Author(s)
      松元奈緒美、平郁子、中西真弓、二井將光
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of organelles with V-ATPase a3 subunit in osteoclasts2009

    • Author(s)
      Naomi Matsumoto、Mayumi Nakanishi -Matsui、Ikuko Taira、Masamitsu Futai
    • Organizer
      JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
    • Place of Presentation
      岩手医科大学矢巾キャンパス
    • Year and Date
      2009-07-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Characterization of organelles with V-ATPase a3 subunit in osteoclasts2009

    • Author(s)
      Naomi Matsumoto, Mayumi Nakanishi-Matsui, Ikuko Taira, Masamitsu Futai
    • Organizer
      JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
    • Place of Presentation
      岩手県紫波郡矢巾町岩手医科大学矢巾キャンパス
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi