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Study on a nove暮Iipid transfer protein that mediates the intraceHular trafficking of phosphoJipid to mitochondria

Research Project

Project/Area Number 20770091
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Structural biochemistry
Research InstitutionDokkyo Medical University

Principal Investigator

HORIBATA Yasuhiro  Dokkyo Medical University, 医学部, 助教 (80392116)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsリン脂質 / ホスプアチジルコリン / StarD / ミトコンドリア / 脂質 / 生体分子
Research Abstract

Phosphatidylcholine (PC) is the major constituent of both mitochondrial inner and outer membranes. Because mltochondria do not contain the sequential enzymes needed for PC production, they must import it from the site of biosynthesis such as the endoplasmlc retlculum and Golgi complex. Up to daLe, the specific molecules responsible for the transport of PC to mitochondrla have not been well characterized. In the present study, a novel lipid transfer protein involved ln the intracellular trafficking of PC to mitochondria is identified and characterized.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondrla.2010

    • Author(s)
      Horibata, Y., Sugimoto, H.
    • Journal Title

      J. Biol. Chem 285

      Pages: 7358-7365

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] StarD7 mediates the intracellular trafficking of phosphatidylcholine tomitochondria.2010

    • Author(s)
      Horibata, Yasuhiro, Sugimoto, Hiroyuki
    • Journal Title

      Journal of Biological Chemistry. Vol.285

      Pages: 7358-7365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] リン脂質をミトコンドリアへ輸送する新規タンパク質の機能解明2009

    • Author(s)
      堀端康博
    • Organizer
      第37回獨協医学会
    • Place of Presentation
      栃木
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン脂質をミトコンドリア-輸送する新規タンパク質の機能解明2009

    • Author(s)
      堀端康博
    • Organizer
      第3 7回濁協医学会
    • Place of Presentation
      栃木
    • Related Report
      2009 Final Research Report
  • [Presentation] リン脂質輸送タンパク質StarD7の生化学的解析と細胞内局在2008

    • Author(s)
      堀端康博
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      徳島
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン脂質輸送タンパク質starD7の生化学的解析と細胞内局在2008

    • Author(s)
      堀端康博、杉本博之
    • Organizer
      第50回日本脂質生化学会
    • Place of Presentation
      徳島
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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