| Project/Area Number |
20770091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
HORIBATA Yasuhiro Dokkyo Medical University, 医学部, 助教 (80392116)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | リン脂質 / ホスプアチジルコリン / StarD / ミトコンドリア / 脂質 / 生体分子 |
|---|
| Research Abstract |
Phosphatidylcholine (PC) is the major constituent of both mitochondrial inner and outer membranes. Because mltochondria do not contain the sequential enzymes needed for PC production, they must import it from the site of biosynthesis such as the endoplasmlc retlculum and Golgi complex. Up to daLe, the specific molecules responsible for the transport of PC to mitochondrla have not been well characterized. In the present study, a novel lipid transfer protein involved ln the intracellular trafficking of PC to mitochondria is identified and characterized.
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