Genetic screening for key factors that link development and energy homeostasis using C. elegans
| Project/Area Number |
20770097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MASAMITSU Fukuyama The University of Tokyo, 大学院・薬学系研究科, 助教 (20422389)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞情報伝達機構 / 線虫 / C.elegans / AMPK / インスリン / PTEN / Foxo / 個体発生 / 恒常性 |
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| Research Abstract |
Animal development is greatly influenced by nutrient status, and growth of each organ is precisely coordinated according to the body size. Although derangement of nutrient-dependent growth is thought to be associated with tumorigenesis, the mechanism that links development with nutrient status remains elusive. In this study, I have obtained several findings which suggest that genetic products called insulin/insulin-like growth factors and Rag play an important role in coordinating development with nutritional conditions.
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Report
(3 results)
Research Products
(18 results)
