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Genetic screening for key factors that link development and energy homeostasis using C. elegans

Research Project

Project/Area Number 20770097
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionThe University of Tokyo

Principal Investigator

MASAMITSU Fukuyama  The University of Tokyo, 大学院・薬学系研究科, 助教 (20422389)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords細胞情報伝達機構 / 線虫 / C.elegans / AMPK / インスリン / PTEN / Foxo / 個体発生 / 恒常性
Research Abstract

Animal development is greatly influenced by nutrient status, and growth of each organ is precisely coordinated according to the body size. Although derangement of nutrient-dependent growth is thought to be associated with tumorigenesis, the mechanism that links development with nutrient status remains elusive. In this study, I have obtained several findings which suggest that genetic products called insulin/insulin-like growth factors and Rag play an important role in coordinating development with nutritional conditions.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2010 2009 2008

All Journal Article (2 results) Presentation (16 results)

  • [Journal Article] アミノ酸シグナル伝達に介在するGタンパク質Rag2010

    • Author(s)
      春日秀文、福山征光、紺谷圏二、堅田利明
    • Journal Title

      細胞 42巻3号

      Pages: 20-23

    • Related Report
      2009 Final Research Report
  • [Journal Article] アミノ酸シグナル伝達に介在するG蛋白質 Rag2010

    • Author(s)
      春日秀文
    • Journal Title

      細胞 The CELL 42

      Pages: 20-23

    • Related Report
      2009 Annual Research Report
  • [Presentation] The insulin/IGF signaling and Rag-mediated pathways couple nutrients and stem cell quiescence in C. elegans2009

    • Author(s)
      福山征光、佐久健介、朴梨瑛、下村裕 美、春日秀文、Ann Rougvie、堅田利明
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] The insulin/IGF signaling and Rag-mediated pathways couple nutrients and stem cell quiescence in C.elegans2009

    • Author(s)
      福山征光
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線虫C. elegansを用いたAMPKの各組織のおける飢餓応答の解明2009

    • Author(s)
      佐久間健介、朴梨瑛、福山征光、堅田利明
    • Organizer
      第31回日本分子生物学会・第81回日本生化学会合同大会BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2009-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫C. elegansを用いたTOR経路に関わる新規因子の探索と解析2009

    • Author(s)
      春日秀文、福山征光、堅田利明
    • Organizer
      ファーマ・バイオフォーラム2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫C.elegansを用いたTOR経路に関わる新規因子の探索と解析2009

    • Author(s)
      春日秀文
    • Organizer
      ファーマ・バイオフォーラム2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Arf-like GTPase ARL-8 is required for lysosome biogenesis in C.elegans2009

    • Author(s)
      中江郁青
    • Organizer
      第17回国際C.elegans 学会
    • Place of Presentation
      米国・ロスアンゼルス
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distinct control of survival, and somatic and germline development during L1 diapause by the insulin/IGF signaling and AMPK pathway2009

    • Author(s)
      Fukuyama M, Sakuma K, Astumi Y, Shimomura H, Kasuga H, Rougvie A, Katada T
    • Organizer
      17th International C. elegans Meeting
    • Place of Presentation
      米国ロスアンゼルス
    • Year and Date
      2009-06-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Distinct control of survival, and somatic and germline development during L1 diapause by the insulin/IGF signaling and AMPK pathway2009

    • Author(s)
      福山征光
    • Organizer
      第17回国際C.elegans 学会
    • Place of Presentation
      米国・ロスアンゼルス
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線虫C. elegansを用いたTOR経路の新規因子探索2009

    • Author(s)
      春日秀文、福山征光、堅田利明
    • Organizer
      文部科学省特定領域研究「生体膜トランスポートソームの分子構築と生理機能」「細胞情報ネットワークを統合するg蛋白質シグナル研究の新展開」合同若手ワークショップ
    • Place of Presentation
      神戸
    • Year and Date
      2009-01-30
    • Related Report
      2009 Final Research Report
  • [Presentation] アミノ酸シグナルにおけるRagの機能解析2009

    • Author(s)
      福山征光、下村裕美、長屋涼太郎、春日 秀文、田杭靖丈、壱岐和哉、伊藤有 佳子、梶保博昭、紺谷圏二、堅田利明
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫C. elegansを用いたAMPKの各組織のおける飢餓応答の解明2008

    • Author(s)
      佐久間健介
    • Organizer
      第31回日本分子生物学会・第81回日本生化学会合同大会BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 線虫C. elegansを用いたTOR経路で機能する新規因子の探索2008

    • Author(s)
      長屋涼太郎、福山征光、堅田利明
    • Organizer
      ファーマ・バイオフォーラム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫C. elegansを用いたTOR経路で機能する新規因子の探索2008

    • Author(s)
      長屋涼太郎
    • Organizer
      ファーマ・バイオラォーラム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 線虫C. elegansを用いたAMPKの各組織における飢餓応答の解明2008

    • Author(s)
      佐久間健介、朴梨瑛、福山征光、堅田利明
    • Organizer
      東京大学生命科学ネットワークシンポジウム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫C. elegansを用いたAMPKの各組織における飢餓応答の解明2008

    • Author(s)
      佐久間健介
    • Organizer
      東京大学生命科学ネヅトワークシンポジウム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 線虫を用いたインスリン/IGFシグナル経路の研究2008

    • Author(s)
      福山征光、朴梨瑛、渥美由梨子、佐久間 健介、下村裕美、長屋涼太、紺谷圏 二、堅田利明
    • Organizer
      第7回生命科学研究会
    • Place of Presentation
      別府
    • Year and Date
      2008-05-29
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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