Study of functional and physical interactions between an amino acid transporter complex LAT1-4F2hc and Integrin by using Reconstituted proteoliposomes
| Project/Area Number |
20770101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
NAGAMORI Shushi Osaka University, 医学系研究科, 助教 (90467572)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | トランスポーター / プロテオリポソーム / 膜複合体 / ガン |
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| Research Abstract |
LAT1(L-type amino acid transporter 1) is one of the transporters which uptake essential amino acids. Expression of the function requires an interacting partner, CD98/4F2hc. In this study, a new experimental system has been developed to study LAT1-function in detail and it is shown that CD98/4F2hc is not essential for the function. Furthermore, Annexine II was identified as a CD98/4F2hc -binding protein beside integrin.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15- hydroxylprostaglandindehydrogenase in renal proximal tubules2010
Author(s)
Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, Kanai Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A novel role of the C-terminus of b0, +AT in the ER-Golgi trafficking of the rBAT-b0, +AT heterodimeric amino acid transporter2009
Author(s)
Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.
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Journal Title
Biochem J. 417
Pages: 441-448
Related Report
Peer Reviewed
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[Journal Article] Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia2008
Author(s)
Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, Shinomiya N.
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Journal Title
Am J Hum Genet. 83
Pages: 744-751
Related Report
Peer Reviewed
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