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Functional analysis of atypical nuclear small GTP-binding protein

Research Project

Project/Area Number 20770103
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionNara Institute of Science and Technology

Principal Investigator

TAGO Kenji  Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (20306111)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞情報伝達機構 / シグナル伝達 / 細胞・組織 / 蛋白質 / がん / 癌
Research Abstract

We found that κB-Ras is a novel type of nuclear-cytoplasmic small GTPase that mainly binds to GTP, and its localization seemed to be regulated by its GTP/GDP-binding state. Unexpectedly, the GDP-binding form of κB-Ras mutant exhibited a more potent inhibitory effect on NF-κB activation, and this inhibitory effect seemed to be due to suppression of the transactivation of a p65/RelA NF-κB subunit.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (7 results)

  • [Journal Article] Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination.2010

    • Author(s)
      Nagai Y, Nishimura A, Tago K, Mizuno N, Itoh H.
    • Journal Title

      J Biol Chem. 285(15)

      Pages: 11114-11120

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination.2010

    • Author(s)
      Nagai Y
    • Journal Title

      J Biol Chem. 285(15)

      Pages: 11114-11120

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Licochalcone A potently inhibits TNF・-induced NF-κB activation through the direct inhibition of IKK activation.2009

    • Author(s)
      Funakoshi-Tago M, Tanabe S, Tago K, Itoh H, Mashino T, Sonoda Y, Kasahara T.
    • Journal Title

      Mol Pharmacol. 76(4)

      Pages: 745-53

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.2009

    • Author(s)
      Abe M, Funakoshi-Tago M, Tago K, Kamishimoto J, Aizu-Yokota E, Sonoda Y, Kasahara T.
    • Journal Title

      Int Immunopharmacol. 9(7-8)

      Pages: 870-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor.2009

    • Author(s)
      Nakata A, Urano D, Fujii-Kuriyama Y, Mizuno N, Tago K, Itoh H.
    • Journal Title

      EMBO Rep. 10(6)

      Pages: 622-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice.2009

    • Author(s)
      Funakoshi-Tago M, Tago K, Sumi K, Abe M, Aizu-Yokota E, Oshio T, Sonoda Y, Kasahara T.
    • Journal Title

      J Biol Chem. 284(19)

      Pages: 12680-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-κB p65 phosphorylation at serine 276.2009

    • Author(s)
      Furusawa J, Funakoshi-Tago M, Tago K, Mashino T, Inoue H, Sonoda Y, Kasahara T.
    • Journal Title

      Cell Signal. 21(5)

      Pages: 778-85

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRAF6 negatively regulates TNF・-induced NF-κB activation.2009

    • Author(s)
      Funakoshi-Tago M, Kamada N, Shimizu T, Hashiguchi Y, Tago K, Sonoda Y, Kasahara T.
    • Journal Title

      Cytokine. 45(2)

      Pages: 72-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] G-protein signaling negatively regulates the stability of aryl hydrocarbon receptor.2009

    • Author(s)
      Nakata A
    • Journal Title

      EMBO Rep. 10(6)

      Pages: 622-628

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Licochalcone A potently inhibits TNFα-induced NF-κB activation through the direct inhibition of IKK activation.2009

    • Author(s)
      Funakoshi-Tago M
    • Journal Title

      Mol Pharmacol. 285(8)

      Pages: 5296-5307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G-protein signaling negatively regulates the stability of aryl hydrocarbon receptor2009

    • Author(s)
      Nakata A
    • Journal Title

      EMBO Rep(発表予定) (未定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] icochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation.2008

    • Author(s)
      Funakoshi-Tago M, Tago K, Nishizawa C, Takahashi K, Mashino T, Iwata S, Inoue H, Sonoda Y, Kasahara T.
    • Journal Title

      Biochem Pharmacol. 76(12)

      Pages: 1681-93

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.2008

    • Author(s)
      Funakoshi-Tago M, Tago K, Kasahara T, Parganas E
    • Journal Title

      Ihle JN. Cell Signal. 20(11)

      Pages: 1995-2001

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Celecoxib potently inhibits TNF・-induced nuclear translocation and activation of NF-κB2008

    • Author(s)
      Funakoshi-Tago M, Shimizu T, Tago K, Nakamura M, Itoh H, Sonoda Y, Kasahara T.
    • Journal Title

      Biochem Pharmacol. 76(5)

      Pages: 662-71

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRAF6 is a critical signal transducer in IL-33 signaling pathway.2008

    • Author(s)
      Funakoshi-Tago M, Tago K, Hayakawa M, Tominaga S, Ohshio T, Sonoda Y, Kasahara T.
    • Journal Title

      Cell Signal. 20(9)

      Pages: 1679-86

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein bg subunits and PKA.2008

    • Author(s)
      Urano D, Nakata A, Mizuno N, Tago K, Itoh H.
    • Journal Title

      Cell Signal. 20(8)

      Pages: 1545-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Domain-domain interaction, of P-Rexl is essential for the activation and inhibition by G protein betagamma subunits and PKA2008

    • Author(s)
      Urano D
    • Journal Title

      Cell Signal 20(8)

      Pages: 1545-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway.2008

    • Author(s)
      Iguchi T
    • Journal Title

      J Biol Chem 283 (21)

      Pages: 14469-78

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Structural basis of a novel targeting site for the specific inhibition of heterotrimeric G proteins2009

    • Author(s)
      西村明幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Related Report
      2009 Final Research Report
  • [Presentation] Gタンパク質シグナルによるdoublecortinのリン酸化と細胞遊走の解析2009

    • Author(s)
      吉田真奈美
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Related Report
      2009 Final Research Report
  • [Presentation] 三量体Gタンパク質G・sのユビキチン化はRic-8Bとの結合により抑制される2009

    • Author(s)
      永井裕介
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Related Report
      2009 Final Research Report
  • [Presentation] Ric-8B accelerates Gs signaling through the stabilization of the a subunit of stimulatory G protein2009

    • Author(s)
      永井裕介
    • Organizer
      The American Society for Cell Biology 49th annualmeeting
    • Place of Presentation
      米国San Diego, CA
    • Related Report
      2009 Annual Research Report
  • [Presentation] NF-κB活性化に対する低分子量GTP結合タンパク質κB-Rasの抑制機構あ解析2008

    • Author(s)
      向縄昌輝
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] NF-κBシグナルに対する哺乳動物の2種類のRic-8の作用2008

    • Author(s)
      加戸美奈
    • Organizer
      31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Related Report
      2009 Final Research Report
  • [Presentation] NF-κB活性化に対する低分子量GTP結合タンパク質κB-Rasの抑制機構の解析2008

    • Author(s)
      向縄昌輝
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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