Analysis of chondroitin proteoglycans and related molecules involved in cell division control

• Project/Area Number: 20770104
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional biochemistry
• Research Institution: Kyushu University
• Principal Investigator: MIZUGUCHI Souhei Kyushu University, 大学院・生命科学研究部, 産学官連携研究員 (50398103)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖鎖 / C. elegans / 細胞分裂 / C.elegans

Research Abstract

Chondroitin proteoglycans are involved in cell division. We analysed chondroitin proteoglycans and related molecules using model organism C. elegans and found following. 1) Two chondroitin proteoglycans are required for proper assembly of the C. elegans eggshell and osmotic barriear. 2) Chondroitin plays an important role on meiosis in nematode germ line. 3) Chondroitin proteoglycans are imvolved in receptor-mediated transport of vitellogenin during oogenesis. These findings suggest that chondroitin and related molecules are involved in cell division control and molecular transport systems.

Research Products

• [Journal Article] The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans (2009)
  • Author(s): Dejima K, Murata D, Mizuguchi S, Nomura KH, Gengyo-Ando K, Mitani S, Kamiyama S, Nishihara S, Nomura K
  • Journal Title: FASEB Journal 23 Pages: 2215-2225
  • Peer Reviewed
• [Journal Article] Kazuya Sulfation and related genes in Caenorhabditis elegans"線虫における硫酸化と関連遺伝子" (2009)
  • Author(s): Mizuguchi, Souhei, Dejima, Katsufumi, Nomura
  • Journal Title: Trends in Glycoscience and Glycotechnology 21 Pages: 179-191
  • Peer Reviewed
• [Journal Article] The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. (2009)
  • Author(s): Dejima K, Murata D, Mizuguchi S, Nomura KH, Gengyo-Ando K, Mitani S, Kamiyama S, Nishihara S, Nomura K
  • Journal Title: FASEB Journal 23 Pages: 2215-2225
  • Peer Reviewed
• [Journal Article] Sulfation and related genes in Caenorhabditis elegans (2009)
  • Author(s): Mizuguchi, Souhei, Dejima, Katsufumi, Nomura, Kazuya
  • Journal Title: Trends in Glycoscience and Glycotechnology 21 Pages: 179-191
  • NAID: 10026976648
  • Peer Reviewed
• [Journal Article] The ortholog of human solute carrier family 35 member B1 (UDP-galactose transpo rter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans (2009)
  • Author(s): Katsufumi Dejima, et.al.
  • Journal Title: The FASEB Journal (Published onli ne March 6)
  • Peer Reviewed
• [Presentation] 統合プロテオミクスとバイオインフォマティクスの手法を用いた脳腫瘍の化学治療感受性に関するVimentinを介したネットワークの解析 (2009)
  • Author(s): 水口惣平, 他.
  • Organizer: 第82回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-22
• [Presentation] モデル生物C. elegansを用いたコンドロイチンプロテオグリカンの生体内機能解析 (2008)
  • Author(s): 水口惣平, 他.
  • Organizer: 弟31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド・神戸国際展示場
  • Year and Date: 2008-12-11
• [Presentation] モデル生物C. elegansを用いたコンドロイチンプロテオグリカンの生体内機能解析 (2008)
  • Author(s): 水口惣平, et.al.
  • Organizer: 第31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド・神戸国際展示場
  • Year and Date: 2008-12-11
• [Book] Eperimental Glycoscience (2008)
  • Author(s): Mizuguchi Souhei, et al.
  • Total Pages: 516
  • Publisher: Springer
• [Book] Eperimental Glycoscience, section 8 (2008)
  • Author(s): Mizuguchi Souhei, et.al.
  • Total Pages: 5
  • Publisher: Springer
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
• [Remarks] 九州大学理学研究院生物科学部門情報生物学講座(野村一也研究室Webページ)
  • URL: http://seibutsu.biology.kyushu-u.ac.jp/nomura/index.html
• [Patent(Industrial Property Rights)] 融合プロテオミクスによるデータマイニングシステム及びデータマイニング方法 (2010)
  • Inventor(s): 荒木令江、水口惣平, 他
  • Industrial Property Rights Holder: 熊本大学
  • Filing Date: 2010-03-31
• [Patent(Industrial Property Rights)] 抗癌剤の効果を飛躍的に向上させる補助薬としての翻訳後修飾阻害剤 (2010)
  • Inventor(s): 荒木令江、水口惣平, 他
  • Industrial Property Rights Holder: 熊本大学
  • Filing Date: 2010-03-31
• [Patent(Industrial Property Rights)] 融合プロテオミクスによるデータマイニングシステム及びデーロマイニング方法 (2010)
  • Inventor(s): 荒木令江 水口惣平, 他
  • Industrial Property Rights Holder: 熊本大学
  • Industrial Property Number: 2010-081525
  • Filing Date: 2010-03-31
• [Patent(Industrial Property Rights)] 抗癌剤の効果を飛躍的に向上させる補助薬としての翻訳後修飾阻害剤 (2010)
  • Inventor(s): 荒木令江 水口惣平, 他
  • Industrial Property Rights Holder: 熊本大学
  • Industrial Property Number: 2010-081524
  • Filing Date: 2010-03-31