| Project/Area Number |
20770108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
YAMAGUCHI Hideki Tokyo University of Pharmacy and Life Science, 生命科学部, 講師 (10345035)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞情報伝達機構 / イノシトールリン脂質代謝 / ホスホリパーゼC / ミオシン / 内耳有毛細胞 / エンドサイトーシス / 微絨毛形成 / イノシトールリン脂質 |
|---|
| Research Abstract |
In this study, we performed functional analyses of phospholipase Cδ3, an enzyme involved in phosphoinositide metabolism, and its binding protein Myosin VI, a motor protein involved in molecular transport. As a result, we revealed that these proteins are coexpressed in the inner hair cells in mice and colocalized on the plasma membrane in cultured cells. Furthermore, we found that phospholipase Cδ3 regulates several cellular processes which depends on Myosin VI function, such as endocytosis and microvilli formation.
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