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Ubiquitylation involved in Parkinson disease and membrane repair

Research Project

Project/Area Number 20770112
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

MATSUDA Noriyuki  Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 (10332272)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsユビキチン / パーキンソン病 / Parkin / PINK1 / 細胞膜修復 / MG53 / RING finger motif
Research Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of genes linked to familial forms of PD, such as Parkin and PINK1, has revealed that ubiquitylation and mitochondrial integrity are key factors in disease pathogenesis. However, the exact mechanism underlying the functional interplay between Parkin-catalyzed ubiquitylation and PINK1-regulated mitochondrial quality control remains an enigma. We revealed the concrete mechanism underlying the functional interplay between ubiquitylation catalyzed by Parkin and mitochondrial quality control regulated by PINK1. These results provide crucial insight into the pathogenic mechanisms of PD. We also revealed that MG53 ubiquitin ligase is involved in plasma-membrane repair.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) Remarks (2 results)

  • [Journal Article] Clement A Gautier, Yu-shin Sou, Shinji Saiki, Sumihiro Kawajiri, Fumiaki Sato, Mayumi Kimura, Masaaki Komatsu, Nobutaka Hattori and Keiji Tanaka2010

    • Author(s)
      Noriyuki Matsuda, Shigeto Sato, Kahori Shiba, Kei Okatsu, Keiko Saisho
    • Journal Title

      PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. Journal of Cell Biology 189(2)

      Pages: 211-221

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010

    • Author(s)
      Noriyuki Matsuda, Keiji Tanaka
    • Journal Title

      Journal of Cell Biology 189(2)

      Pages: 211-221

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MG53 nucleates assembly of cell membrane repair machinery.2009

    • Author(s)
      Chuanxi Cai, Haruko Masumiya, Noah Weisleder, Noriyuki Matsuda, Miyuki Nishi, Moonsun Hwang, Jae-Kyun Ko, Peihui Lin, Angela Thornton, Xiaoli Zhao, Zui Pan1, Shinji Komazaki, Marco Brotto, Hiroshi Takeshima, Jianjie Ma
    • Journal Title

      Nat Cell Biol 11(1)

      Pages: 56-64

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] MG53 nucleates assembly of cell membrane repair machinery.2009

    • Author(s)
      Chuanxi Cai, Haruko Masumiya, Noah Weisleder, Noriyuki Matsuda, Miyuki Nishi, Moonsun Hwang, Jae-Kyun Ko, Peihui Lin, Angela Thornton, Xiaoli Zhao, Zui Panl, Shinji Komazaki, Marco Brotto, Hiroshi Takeshima and Jianjie Ma
    • Journal Title

      Nature Cell Biology 11(1)

      Pages: 56-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] PINK1 recruits Parkin to damaged mitochondria for degradation.2010

    • Author(s)
      Noriyuki Matsuda
    • Organizer
      The 2nd International Symposium of NCRC "Mitochondria and Autophagy in Neurodegenerative Diseases"
    • Place of Presentation
      Kyung Hee University, Seoul, Korea (招待講演).
    • Year and Date
      2010-02-08
    • Related Report
      2009 Final Research Report
  • [Presentation] PINK1 recruits Parkin to damaged mitochondria for degradation2010

    • Author(s)
      Noriyuki Matsuda
    • Organizer
      The 2nd International Symposium of NCRC
    • Place of Presentation
      韓国・ソウル市・Kyung Hee University
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] パーキンソン病は, 膜電位を失ったミトコンドリアに対する品質管理不全病である2009

    • Author(s)
      松田憲之, 佐藤栄人, 柴佳保里, 尾勝圭, 税所慶子, 曽友深, 斉木臣二, 河尻澄宏, 里史明, 木村まゆみ, 小松雅明, 服部信孝, 田中啓二
    • Organizer
      第32回日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] パーキンソン病は膜電位を失ったミトコンドリアのQuality control diseaseである2009

    • Author(s)
      松田憲之, 田中啓二
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Final Research Report
  • [Presentation] Parkin is retrieved from the cytoplasm to depolarized mitochondria, and triggers its degradation.2009

    • Author(s)
      Noriyuki Matsuda
    • Organizer
      5th International Symposium on Autophagy
    • Place of Presentation
      Otsu, Shiga, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] パーキンソン病は膜電位を失ったミトコンドリアのQuality control diseaseである.2009

    • Author(s)
      松田憲之, 田中啓二
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] Parkin is retrieved from the cytoplasm to depolarized mitochondria, and triggers its degradation.2009

    • Author(s)
      Noriyuki Matsuda
    • Organizer
      5th International Symposium on Autophagy
    • Place of Presentation
      滋賀県・大津市
    • Related Report
      2009 Annual Research Report
  • [Presentation] パーキンソン病は,膜電位を失ったミトコンドリアに対する品質管理不全病である.2009

    • Author(s)
      松田憲之, 田中啓二, ら
    • Organizer
      第32回日本分子生物学会大会
    • Place of Presentation
      パシフイコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 内在性Parkinの存在様式および細胞内局在の再検討2008

    • Author(s)
      税所慶子, 和栗聡, 上野隆, Klavs Hendil, 佐藤栄人, 服部信孝, 田中啓二, 松田憲之
    • Organizer
      第81回日本生化学会大会(日本生化学会+日本分子生物学会, 合同大会)
    • Place of Presentation
      神戸(ポートアイランド)
    • Related Report
      2008 Annual Research Report
  • [Remarks] 研究成果をホームページで公表

    • URL

      http://www.rinshoken.or.jp/activities/t100419.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/activities/t100419.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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