Functional analysis of structural proteins of the axonemal inter-doublet links
| Project/Area Number |
20770119
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
YANAGISAWA Haruaki The University of Tokyo, 大学院・理学系研究科 (70466803)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 細胞運動 / 鞭毛・繊毛 / 生体分子 / 生物物理 |
|---|
| Research Abstract |
The outer doublet microtubules in ciliary and flagellar axonemes are connected with each other by elastic links called the interdoublet (nexin) links. This structures are important for maintenance of axonemal structure and converting sliding between doublets into bending. The link has been found in early electron microscopic studies, but little is known about its molecular composition. In this study I cloned putative nexin components from partially extracted axonemes, in which outer doublets remained connected together. Localization and mutational analyses confirmed the involvement of these components in the nexin links.
|
Report
(3 results)
Research Products
(7 results)
