| Project/Area Number |
20770123
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
KOSHIBA Takumi Kyushu University, 理学研究院, 准教授 (70403970)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | ミトコンドリア / RNAウイルス / 自然免疫 / シグナル伝達 / インターフェロン / 抗ウイルス免疫 / MAVS / Mitofusin 2 / インターフェロンβ / 蛋白質科学 |
|---|
| Research Abstract |
Innate cellular immune response to viral infection results in the activation of multiple signaling steps, ultimately regulates the expression of type-I interferons (IFNs), and a mitochondrial membrane protein, MAVS plays an important role in the pathway. In the presence study, we found that mitofusin 2 (Mfn2), a mediator of mitochondrial fusion, cooperates with MAVS, and participates in the antiviral immunity. Our results suggest that Mfn2 acts as a negative regulator for antiviral signaling, and would have a distinct function unrelated to mitochondrial dynamics.
|
