| Project/Area Number |
20770124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
OTSUBO Yoshitaka Kyushu Institute of Technology, 生命体工学研究科, 助教 (00380725)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 受容体 / イオンチャネル / 味覚器 / 細胞型 / 味蕾細胞 / コネキシン / ヘミチャネル / 電位依存性 / 味情報伝播 |
|---|
| Research Abstract |
Connexins, membrane proteins form two types of corridors for small molecules (molar mass <～1000). One is gap junctions between cells, and another is hemichannels between inside and outside the cell. I show that taste bud cells expressed a few connexin subtypes, and that there are few dye-coupling among taste bud cells. These results suggest that connexins play an important role as hemichannels rather than gap junctions. The role of hemichannels is discussed.
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