Study on the function of the transcriptional repressor Fbl10 in the regulation of c-Jun

Research Project

Project/Area Number	20770154
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cell biology
Research Institution	The University of Tokyo
Principal Investigator	NASU Ryo The University of Tokyo, 分子細胞生物学研究所, 助教 (30466859)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	クロマチン / 細胞周期 / c-Jun / JmjC / HP1 / JmiC / C-Jun
Research Abstract	The transcriptional repressor Fbl10 is found to cooperate with Heterochromatin Protein 1 γ (HP1γ) to repress c-jun transcription. Moreover, HP1γ is dispensable for the tumorigenicity of colon cancer cells. Therefore, the increase of c-Jun by HP1γ repression may be involved in the induction of cell death, rather than the promotion of G1/S transition of cell cycle.

Report

(3 results)