| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. Here we show that, even cultured cells lacking the mitochondrial fission GTPase Drp1 are normal, Drp1-KO mice have developmental abnormalities, die after embryonic day 12.5. Neural cell-specific Drp1-KO mice die shortly after birth as a result of brain hypoplasia with apoptosis.
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