| Project/Area Number |
20770157
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
MORITA Tsuyoshi Osaka University, 医学系研究科, 助教 (80403195)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 細胞骨格 / 細胞運動 / 癌 / 転移 / 浸潤 |
|---|
| Research Abstract |
In this study, I demonstrated that transcription factor MRTF (myocardin-related transcription factor) regulates the activity of cell invasion and metastasis in the v-ras and v-src transformants via transcriptional regulation of the actin cytoskeletal genes. Further, myocardin regulates the expression of p21 gene, which is inhibitor of cell cycle progression, and in leiomyosarcoma cells myocardin expression level is decreased, leading to enhancement of cell cycle progression. Exogenous expression of constitutively active MRTF or myocardin inhibits the oncogenic properties of the transformants and leimyosarcoma cells.
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