Role of PSTPIP2, an autoinflammatory disorder-associated protein, in cell migration

Research Project

Project/Area Number	20770158
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cell biology
Research Institution	Kobe University
Principal Investigator	TSUJITA Kazuya Kobe University, 大学院・医学研究科, 助教 (10457054)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	細胞骨格 / 細胞内シグナル伝達ファゴサイトーシス / 細胞内シグナル伝達 / 細胞膜 / Phagocytosis
Research Abstract	It was shown that PSTPIP2 is a negative regulator of phagocytosis. It is suggested that PSTPIP2 is localized to the nascent cup, where it suppress the robust actin polymerization. The localization of PSTPIP2 to the nascent cup is dependent on its lipid binding ability. In addition, PSTPIP2 is tyrosine phosphorylated following phagocytosis and its phosphorylation dissociates it from the nascent cup. Thus, PSTPIP2 is the novel negative regulator of phagocytosis though inhibiting phagocytic cup formation that is controlled by its tyrosine phosphorylation.

Report

(3 results)