Analysis of the molecular mechanism regulating target gene selection

• Project/Area Number: 20770174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: The University of Tokyo
• Principal Investigator: KOSHIDA Sumito The University of Tokyo, 大学院・理学系研究科, 准教授 (40342638)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 遺伝子発現調節 / 発現制御 / 発生・分化 / 遺伝学 / 遺伝子 / シグナル伝達

Research Abstract

During vertebrate development, the same signaling molecule is often expressed repeatedly and plays an important role in each time and place. This means the same signal can differently regulate the expression of genes in each case. This differential control of gene expression is probably caused by differential competence of the cells in response to signals. In this research, we will analyze the phenotype of zebrafish mutants which are defective for the differential control of gene expression and identify their responsible genes, and try to understand the molecular mechanism underlying the differential competence.