Functions of axon guidance receptors, plexins, in the developing hippocampus

• Project/Area Number: 20770184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Tohoku University
• Principal Investigator: SUTO Fumikazu Tohoku University, 大学院・医学系研究科, 助教 (40345848)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 神経科学 / 発生生物(学) / 神経発生(学) / 遺伝子 / 発生・分化 / 脳・神経 / 分子局在 / 軸索誘導 / 神経回路形成 / プレキシン / 細胞移動 / 器官形成 / 神経回路(網) / 海馬

Research Abstract

We have shown that axon guidance molecule Sema6A and its receptor, plexin-A2 and plexin-A4, regulate the lamina-restricted projection of the hippocampal mossy fibers. We examined the role of semaphoring/plexin signaling in the formation of hippocampal network, and found that the Sema6A/plexin-A4 signaling is required for the sub-dendritc projection of the axons of hippocampal mossy cells. We also identified the molecular domain that is required for the dendritic localization of plexin-A2.

Research Products

• [Journal Article] Roles of Sema6B and Plexin-A2 in mossy fiers projection. (2010)
  • Author(s): Tawarayama, H.、Yoshida, Y.、Suto, F.、Mitchell, KJ.、Fujisawa, H.
  • Journal Title: Journal of Neuroscience 30 Pages: 7049-7060
  • Peer Reviewed
• [Journal Article] Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers (2010)
  • Author(s): Tawarayama H, Yoshida Y, Suto F, Mitchell KJ, Fujisawa H
  • Journal Title: Journal of Neuroscience (未定, 印刷中)
  • Peer Reviewed
• [Journal Article] Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points. (2008)
  • Author(s): Runker, AE.、Little, GE.、Suto, F.、Fujisawa, H.、Mitchell, KJ.
  • Journal Title: Neural Development 3 Pages: 34-34
  • Peer Reviewed
• [Journal Article] セマフォリン/プレキシンシグナルによる神経回路形成機構 (2008)
  • Author(s): 須藤文和
  • Journal Title: 実験医学増刊神経回路の制御と脳機能発現メカニズム Vol.26-No.22
• [Journal Article] Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points (2008)
  • Author(s): Annette E Riinker
  • Journal Title: Neural Develoment 3 Pages: 34-34
  • Peer Reviewed
• [Presentation] 軸索接続における細胞種および細胞部位特異性を制御する分子機構 (2009)
  • Author(s): 須藤文和
  • Organizer: 日本発生生物学会秋期シンポジウム
  • Place of Presentation: 三島市
  • Year and Date: 2009-11-28
• [Presentation] 軸索接続における細胞種および細胞部位特異性を制御する分子機構 (2009)
  • Author(s): 須藤文和
  • Organizer: 発生生物学会秋期シンポジウム
  • Place of Presentation: 東レ総合研修センター(静岡県)
  • Year and Date: 2009-11-28
• [Presentation] Expression of plexin-A subfamily members in the development of amygdaloid circuitry (2009)
  • Author(s): Suto F, Osumi N.
  • Organizer: Construction and Reconstruction of the Brain
  • Place of Presentation: 淡路夢舞台(兵庫県)
  • Year and Date: 2009-10-09
• [Presentation] Role of axon guidance receptor in the development of amygdaloid circuitry (2008)
  • Author(s): 須藤文和、大隅典子
  • Organizer: 第31回日本神経科学学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Role of semaphorin/plexin signaling in the developing nervous system. (2008)
  • Author(s): 須藤文和
  • Organizer: 第41回日本発生生物学会年会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-05-28
• [Presentation] Role of semaphorin/plexin signaling in the developing nervous system (2008)
  • Author(s): 須藤文和
  • Organizer: 第41回日本発生生物学会年会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-05-28
• [Book] セマフォリン/プレキシンシグナルによる神経回路形成機構、実験医学増刊 神経回路の制御と脳機能発現メカニズム、Vol.26-No.22 (2008)
  • Author(s): 須藤文和
  • Publisher: 羊土社