Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Research Abstract |
We have shown that axon guidance molecule Sema6A and its receptor, plexin-A2 and plexin-A4, regulate the lamina-restricted projection of the hippocampal mossy fibers. We examined the role of semaphoring/plexin signaling in the formation of hippocampal network, and found that the Sema6A/plexin-A4 signaling is required for the sub-dendritc projection of the axons of hippocampal mossy cells. We also identified the molecular domain that is required for the dendritic localization of plexin-A2.
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