Functions of axon guidance receptors, plexins, in the developing hippocampus
| Project/Area Number |
20770184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUTO Fumikazu Tohoku University, 大学院・医学系研究科, 助教 (40345848)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経科学 / 発生生物(学) / 神経発生(学) / 遺伝子 / 発生・分化 / 脳・神経 / 分子局在 / 軸索誘導 / 神経回路形成 / プレキシン / 細胞移動 / 器官形成 / 神経回路(網) / 海馬 |
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| Research Abstract |
We have shown that axon guidance molecule Sema6A and its receptor, plexin-A2 and plexin-A4, regulate the lamina-restricted projection of the hippocampal mossy fibers. We examined the role of semaphoring/plexin signaling in the formation of hippocampal network, and found that the Sema6A/plexin-A4 signaling is required for the sub-dendritc projection of the axons of hippocampal mossy cells. We also identified the molecular domain that is required for the dendritic localization of plexin-A2.
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Report
(4 results)
Research Products
(12 results)
