Directional control of cell polarization revealed by quantitative measurement and mathematical modeling
| Project/Area Number |
20770187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ARATA Yukinobu The Institute of Physical and Chemical Research, 佐甲細胞情報研究室, 研究員 (40360482)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 画像解析プログラム / 数理モデル / 細胞極性 / 方向制御 / 一分子計測 / タンパク質細胞内動態 / 非対称局在 / PARタンパク質 / 分子生物学 / 細胞生物学 / 発生生物学 |
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| Research Abstract |
Cells polarize along with the axes of the animal body. Cell polarity is maintained by dynamic equilibrium of protein movements. In this study, I succeeded to apply and develop the new systems to reveal protein dynamics quantitatively to developmental biology (Edge-detection image processing program, Fluorescence correlation spectroscopy (FCS), Total internal reflection fluorescence microscope (TIRFM)). Based on the achievements of this study, I will carry out mathematical modeling to understand cell polarization as a dynamical system.
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Report
(4 results)
Research Products
(16 results)
