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Identification of genes associated with differences in facial morphology among individuals and between populations

Research Project

Project/Area Number 20770196
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical anthropology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

KIMURA Ryosuke  University of the Ryukyus, 亜熱帯島嶼科学超域研究推進機構, 特命准教授 (00453712)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords分子 / 遺伝 / 人類学 / ゲノム / 形態
Research Abstract

It is supposed that a number of genetic polymorphisms are associated with the variation in human facial morphology. However, they are still unidentified. In this project, to reveal such genes, 1) anthropometric measurements mainly in craniofacial morphology were performed, 2) based on population genetics analyses, candidate genes were selected from the genes known to be involved in morphogenesis, and then 3) association studies between phenotypes and genotypes were carried out. In several genes such as EDAR, associations with craniofacial morphology including tooth shape were identified.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (13 results) Book (2 results) Remarks (4 results)

  • [Journal Article] The HUGO Pan-Asian SNP Consortium Mapping Human Genetic Diversity in Asia2009

    • Journal Title

      Science 326

      Pages: 1541-1545

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A common variation in EDAR is a genetic determinant of shovel-shaped incisors.2009

    • Author(s)
      Kimura R, Yamaguchi T, Takeda M, Kondo O, Toma T, Haneji K, Hanihara T, Matsukusa H, Kawamura S, Maki K, Osawa M, Ishida H, Oota H.
    • Journal Title

      American Journal of Human Genetics 85

      Pages: 528-535

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] FGFR2 is associated with hair thickness in Asian populations.2009

    • Author(s)
      Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Tsunoda T, Tokunaga K, Ohashi J.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 461-465

    • NAID

      10030731374

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] FGFR2 is associated with hair thickness in Asian populations2009

    • Author(s)
      Fujimoto A, et al.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 461-645

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A common variation in EDAR is a genetic determinant of shovel-shaped incisors2009

    • Author(s)
      Kimura R, et al.
    • Journal Title

      American Journal of Human Genetics 85

      Pages: 528-535

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stature estimation formulae from radio graphically determined limb bone length in a modern Japanese population2009

    • Author(s)
      Hasegawa I, et al.
    • Journal Title

      Legal Medicine 11

      Pages: 260-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mapping human genetic diversity in Asia2009

    • Author(s)
      HUGO Pan-Asian SNP Consortium
    • Journal Title

      Science 326

      Pages: 1541-1545

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene Flow and Natural Selection in Oceanic Human Populations, Inferred from Genome-wide SNP Typing.2008

    • Author(s)
      Kimura R, Ohashi J, Matsumura Y, Nakazawa M, Inaoka T, Ohtsuka R, Osawa M, Tokunaga K.
    • Journal Title

      Molecular Biology and Evolution 25

      Pages: 1750-1761

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia.2008

    • Author(s)
      Fujimoto A, Ohashi J, Nishida N, Miyagawa T, Morishita Y, Tsunoda T, Kimura R, Tokunaga K.
    • Journal Title

      Human Genetics 124

      Pages: 179-185

    • NAID

      120007131497

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene flow and natural selection in Oceanic human populations, inferred from genome-wide SNP typing2008

    • Author(s)
      Kimura R, et.al.
    • Journal Title

      Molecular Biology and Evolution 25

      Pages: 1750-1761

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia2008

    • Author(s)
      Fujimoto A et.tal.
    • Journal Title

      Human Genetics 179-185

      Pages: 179-185

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] シャベル型切歯の遺伝要因2009

    • Author(s)
      木村亮介, 他
    • Organizer
      第14回日本顔学会大会
    • Place of Presentation
      鹿児島大学(鹿児島県)
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] A nonsynonymous SNP in EDAR is associated with tooth shoveling. Poster2009

    • Author(s)
      Kimura R, Yamaguchi T, Maki K, Takeda M, Kondo O, Hanihara T, Osawa M, Ishida H, Kawamura S, Oota H.
    • Organizer
      The American Society of Human Genetics 59th Annual Meeting
    • Place of Presentation
      Hawaii
    • Year and Date
      2009-10-21
    • Related Report
      2009 Final Research Report
  • [Presentation] A nonsynonymous SNP in EDAR is associated with tooth shoveling2009

    • Author(s)
      Kimura R, et al.
    • Organizer
      The 59th Annual Meeting, The American Society of Human Genetics
    • Place of Presentation
      Hawaii Convention Center (Hawaiim, USA)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯形態の遺伝学:シャベル型切歯とEDAR2009

    • Author(s)
      木村亮介, 山口徹太郎, 槇宏太郎, 武田摩耶子, 近藤修, 埴原恒彦, 大澤資樹, 石田肇, 河村正二, 太田博樹
    • Organizer
      第63回日本人類学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯形態の遺伝学:シャベル型切歯とEDAR2009

    • Author(s)
      木村亮介, 他
    • Organizer
      第63回日本人類学会大会
    • Place of Presentation
      シェーンバッハ・サボー(東京都)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] シャベル型切歯とEDAR多型との関連2009

    • Author(s)
      木村亮介, 山口徹太郎, 槇宏太郎, 武田摩耶子, 近藤修, 埴原恒彦, 大澤資樹, 石田肇, 河村正二, 太田博樹
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト形態形質に関連する遺伝子の同定とその戦略. ワークショップ「量的形質研究の展望」2009

    • Author(s)
      木村亮介
    • Organizer
      日本遺伝学会第81回大会
    • Place of Presentation
      松本
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト形態形質に関連する遺伝子的同定とその戦略2009

    • Author(s)
      木村亮介
    • Organizer
      日本遺伝学会第81回大会
    • Place of Presentation
      信州大学(長野県)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 形態形質を担う遺伝子の探索. ワークショップ「ヒト集団の形態変異とゲノム多様性:日本列島(北海道~沖縄)にフォーカスして」2009

    • Author(s)
      木村亮介
    • Organizer
      第11回日本進化学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 形態形質を担う遺伝子の探索2009

    • Author(s)
      木村亮介
    • Organizer
      第11回日本進化学会大会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic differentiation of genes involved in craniofacial anomalies between human populations. Poster2008

    • Author(s)
      Kimura R, Osawa M.
    • Organizer
      The American Society of Human Genetics 58th Annual Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-13
    • Related Report
      2009 Final Research Report
  • [Presentation] ゲノムワイドSNPタイピングチップを用いたオセアニア人類集団における自然選択の探索2008

    • Author(s)
      木村亮介
    • Organizer
      第10回日本進化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic differentiation of genes involved in craniofacial anomalies between human populations2008

    • Author(s)
      Kimura R, Osawa M
    • Organizer
      The American Society of Human Genetics 58th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2008 Annual Research Report
  • [Book] Handbook of Human Molecular Evolution(Cooper DN, Kehrer-Sawatzki eds., Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection., 分担執筆)2008

    • Author(s)
      Kimura R, Ohashi J.
    • Publisher
      Wiley
    • Related Report
      2009 Final Research Report
  • [Book] Handbook of Human Molecular Evolution2008

    • Author(s)
      Cooper DN, Kehrer-Sawatzki Heds
    • Total Pages
      10
    • Publisher
      Wiley
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://w3.u-ryukyu.ac.jp/anthropology/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks] 朝日新聞朝刊2010年1月12日科学面に研究成果が掲載:シャベル型切歯の遺伝子「緑の黒髪」と同じ変異

    • Related Report
      2009 Final Research Report
  • [Remarks] 月刊ジュニアアエラ(朝日新聞出版)2010年3月号に研究成果が掲載:「シャベル型切歯」と「太い黒髪」は同じ遺伝子の変異が原因

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://w3.u-ryukyu.ac.jp/anthropology/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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